Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1 (Q34434226)

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scientific article published on August 8, 1997

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English	Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1	scientific article published on August 8, 1997

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1 (English)

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

author name string

E. D. Fixman

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242692

9 November 2024

M. Holgado-Madruga

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242692

9 November 2024

L. Nguyen

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242692

9 November 2024

D. M. Kamikura

4

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9 November 2024

T. M. Fournier

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9242692

9 November 2024

A. J. Wong

6

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9 November 2024

M. Park

7

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Europe PubMed Central

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9 November 2024

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publication date

1 August 1997

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2 August 2017

8 August 1997

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9242692

9 November 2024

full work available at URL

http://www.jbc.org/article/S002192581838904X/pdf

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9 November 2024

https://api.elsevier.com/content/article/PII:S002192581838904X?httpAccept=text/xml

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

https://api.elsevier.com/content/article/PII:S002192581838904X?httpAccept=text/plain

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.272.32.20167

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

2 August 2017

272

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Europe PubMed Central

PubMed publication ID

2 August 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

20167-20172

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Purification and subunit structure of hepatocyte growth factor from rat platelets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Scatter factor/hepatocyte growth factor is essential for liver development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Mechanism of met oncogene activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Oncogenic activation of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Identification of tyrosine 489 in the carboxy terminus of the Tpr-Met oncoprotein as a major site of autophosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.32.20167

21 January 2018

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor

3

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

Cancer Research

7

49

3314

author name string

Zarnegar

publication date

1989

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways

29

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

43

1 reference

10.1074/JBC.272.32.20167

https://api.crossref.org/works/10.1074/JBC.272.32.20167

9 November 2024

Identifiers

10.1074/JBC.272.32.20167

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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