Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. (Q52725312)

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scientific article published on 30 July 2011

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English	Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.	scientific article published on 30 July 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

5

object named as

Gerd Multhaup

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

author name string

Haiqing Hua

1

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Lisa Münter

2

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Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Anja Harmeier

3

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Oleg Georgiev

4

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Walter Schaffner

6

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

publication date

30 July 2011

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Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

Biological Chemistry

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Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

392

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

10

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

919-926

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Copper homeostasis in eukaryotes: teetering on a tightrope

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF).

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: structure-activity studies

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Membrane interactions and metal ion effects on bilayer permeation of the lipophilic ion modulator DP-109.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Putting its fingers on stressful situations: the heavy metal-regulatory transcription factor MTF-1.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Copper, iron and zinc in Alzheimer's disease senile plaques

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Metallothioneins are multipurpose neuroprotectants during brain pathology

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Zinc supplement greatly improves the condition of parkin mutant Drosophila

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

The parkin Mutant Phenotype in the Fly Is Largely Rescued by Metal-Responsive Transcription Factor (MTF-1)

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Evidence for a copper-binding superfamily of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Metallothionein in the central nervous system: Roles in protection, regeneration and cognition

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.084

21 January 2018

Identifiers

10.1515/BC.2011.084

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 May 2018

http://europepmc.org/abstract/MED/21801085

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