Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (Q52560096)

3 May 2018

meta-analysis

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title

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (English)

1 reference

3 May 2018

genome-wide association study

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression (English)

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main subject

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3 May 2018

Jakob Grove

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3 May 2018

Hamdi Mbarek

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Eco de Geus

170

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Patrick F Sullivan

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André Uitterlinden

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André G Uitterlinden

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Glyn Lewis

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Glyn Lewis

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Na Cai

Na Cai

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Paola Giusti-Rodríguez

Paola Giusti-Rodríguez

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Margarita Rivera

119

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Alexander Viktorin

Alexander Viktorin

150

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Rick Jansen

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Eske M Derks

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Lili Milani

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Daniel J Smith

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Thomas F. Hansen

Thomas F Hansen

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Henriette N Buttenschøn

Henriette N Buttenschøn

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Rudolf Uher

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Danielle Posthuma

Danielle Posthuma

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Michael C O'Donovan

Michael C O'Donovan

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Cathryn Lewis

Cathryn M Lewis

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Sven Cichon

Sven Cichon

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Gerome Breen

Gerome Breen

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Lynsey S Hall

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Georg Homuth

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3 May 2018

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC)

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Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

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Hassan S Dashti

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Wesley K Thompson

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Douglas Blackwood

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Gail Davies

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3 May 2018

author name string

Jonathan I R Coleman

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3 May 2018

Cheynna A Crowley

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3 May 2018

Nicholas Eriksson

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Farnush Hassan Farhadi Kiadeh

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Josef Frank

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Héléna A Gaspar

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Michael Gill

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Carsten Horn

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Ming Hu

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Craig L Hyde

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3 May 2018

James A Knowles

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Jacqueline M Lane

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Yihan Li

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Yun Li

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Xiaoxiao Liu

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3 May 2018

23andMe

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3 May 2018

language of work or name

English

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publication date

26 April 2018

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3 May 2018

24 July 2017

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published in

Nature Genetics

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3 May 2018

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7 September 2018

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7 September 2018

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7 September 2018

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Partitioning heritability by functional annotation using genome-wide association summary statistics

7 September 2018

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7 September 2018

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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

7 September 2018

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Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

High loading of polygenic risk in cases with chronic schizophrenia

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

High-throughput sequencing of the synaptome in major depressive disorder

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Sparse whole-genome sequencing identifies two loci for major depressive disorder

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

MAGMA: generalized gene-set analysis of GWAS data

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Integrative analysis of 111 reference human epigenomes

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genetic studies of body mass index yield new insights for obesity biology

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Synaptic, transcriptional and chromatin genes disrupted in autism

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Biological insights from 108 schizophrenia-associated genetic loci

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Obesity-associated variants within FTO form long-range functional connections with IRX3

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

UK biobank data: come and get it.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Transcriptome and genome sequencing uncovers functional variation in humans

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The epidemiology of depression across cultures

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A genome-wide association study of depressive symptoms

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A genome-wide association meta-analysis identifies new childhood obesity loci

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A mega-analysis of genome-wide association studies for major depressive disorder

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Five years of GWAS discovery

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A high-resolution map of human evolutionary constraint using 29 mammals

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Cost of disorders of the brain in Europe 2010.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The size and burden of mental disorders and other disorders of the brain in Europe 2010.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A user's guide to the encyclopedia of DNA elements (ENCODE)

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A map of human genome variation from population-scale sequencing

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Model-based analysis of ChIP-Seq (MACS)

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The HPA axis in major depression: classical theories and new developments

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The Structure of Genetic and Environmental Risk Factors for Common Psychiatric and Substance Use Disorders in Men and Women

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The genetic aetiology of childhood depression: a review

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Genetic epidemiology of major depression: review and meta-analysis

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The Clinical Course of Unipolar Major Depressive Disorders

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

The classification of depressions: a review of contemporary confusion

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5934326

Mortality of patients with mood disorders: follow-up over 34-38 years

7 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

A genome-wide association study of anorexia nervosa

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Genetic contributions to self-reported tiredness.

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

New genetic loci link adipose and insulin biology to body fat distribution

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Biological, clinical and population relevance of 95 loci for blood lipids

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk

1 reference

https://api.crossref.org/works/10.1038%2FS41588-018-0090-3

7 January 2021

10.1038/S41588-018-0090-3

Identifiers

DOI

1 reference

3 May 2018

10.1101/167577

0 references

PMC publication ID

5934326

0 references

1 reference

3 May 2018