Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. (Q52534304)

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scientific article published in March 1999

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English	Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.	scientific article published in March 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Erwin F. Wagner

7

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Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

author name string

Burkart V

1

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Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Wang ZQ

2

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Radons J

3

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Heller B

4

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Herceg Z

5

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Stingl L

6

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Kolb H

8

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

language of work or name

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publication date

1 March 1999

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Europe PubMed Central

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2 May 2018

http://europepmc.org/abstract/MED/10086388

Nature Medicine

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2 May 2018

http://europepmc.org/abstract/MED/10086388

5

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Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

3

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Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

314-319

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Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

Chronic autoimmunity of type I diabetes

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Essential contribution of macrophages to islet cell destruction in vivo and in vitro

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Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

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Endothelial cells as cytotoxic effector cells: cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide

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Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

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Cytokines and nitric oxide in islet inflammation and diabetes

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Islet cell DNA is a target of inflammatory attack by nitric oxide

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STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

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Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets

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Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

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Influence of nicotinamide and pyridine nucleotides on streptozotocin and alloxan-induced pancreatic B cell cytotoxicity

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Structural requirements for inhibitors of poly(ADP-ribose) Polymerase

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Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

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Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced beta cell death in inbred mice

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Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

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Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide

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Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

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Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

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Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

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Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

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Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle

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Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis

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Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

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PARP is important for genomic stability but dispensable in apoptosis

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

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Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase

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Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure

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Long term in vitro effects of streptozotocin, interleukin-1, and high glucose concentration on the activity of mitochondrial dehydrogenases and the secretion of insulin in pancreatic islets

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Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity

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Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay

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Low dose streptozotocin-induced diabetes in mice: reduced IL-2 production and modulation of streptozotocin-induced hyperglycemia by IL-2

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Identifiers

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 May 2018

http://europepmc.org/abstract/MED/10086388

ResearchGate publication ID

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