The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin (Q51547435)

6 April 2018

title

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin (English)

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6 April 2018

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Eleftheria Vardaki

Eleftheria Vardaki

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6 April 2018

Eugenios Daphnis

Eugene Daphnis

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6 April 2018

Ioannis Petrakis

Ioannis Petrakis

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6 April 2018

Stavros Stratakis

Stavros Stratakis

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6 April 2018

Kostas E Perakis

Kostas Perakis

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6 April 2018

Spyros Stratigis

Spyros Stratigis

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6 April 2018

Lydia Nakopoulou

Lydia Nakopoulou

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6 April 2018

author name string

Vasiliki Mavroeidi

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6 April 2018

Andreas Passam

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6 April 2018

Eva Papadogiorgaki

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6 April 2018

Kostas Giannakakis

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6 April 2018

language of work or name

English

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publication date

13 August 2010

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6 April 2018

Nephrology Dialysis Transplantation

published in

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volume

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issue

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6 April 2018

page(s)

498-508

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6 April 2018

Targeting phosphoinositide 3-kinase: moving towards therapy

cites work

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Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

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Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

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Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus

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New immunosuppresor strategies in the treatment of murine lupus nephritis.

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Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice.

21 January 2018

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Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment.

21 January 2018

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Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice.

21 January 2018

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21 January 2018

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Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus

21 January 2018

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Transcriptional repression of interleukin-2 in human systemic lupus erythematosus

21 January 2018

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

21 January 2018

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mTOR signaling at a glance

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

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Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

21 January 2018

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

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Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

21 January 2018

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Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

21 January 2018

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Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis.

21 January 2018

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

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mTOR, cancer and transplantation.

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Signalling through Class I PI3Ks in mammalian cells

21 January 2018

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Temperature sensitivity of phospho-Ser(473)-PKB/AKT.

21 January 2018

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PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.

21 January 2018

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Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

21 January 2018

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Renal activity of Akt kinase in obese Zucker rats

21 January 2018

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mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes

21 January 2018

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Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70(S6K) in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB.

21 January 2018

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Sirolimus interacts with pathways essential for podocyte integrity

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFQ496

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ496

Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ496

21 January 2018

Identifiers

DOI

10.1093/NDT/GFQ496

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6 April 2018

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6 April 2018