Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression (Q57362835)

From Wikidata

Jump to navigation Jump to search

scientific article published on 01 July 1998

Language	Label	Description	Also known as
English	Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression	scientific article published on 01 July 1998

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

Europe PubMed Central

Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

1 reference

based on heuristic

inferred from title

author name string

S N Sehgal

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

publication date

1 July 1998

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Clinical Biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

31

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

335-340

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

New antitumor substances of natural origin

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Activity of rapamycin (AY-22,989) against transplanted tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin: a novel immunosuppressive macrolide

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin: in vitro profile of a new immunosuppressive macrolide

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Effects of cyclosporine and rapamycin on immunoglobulin production by preactivated human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Abrogation by rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and endothelial cell activation, cytokine production, and cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Effects of rapamycin on cultured hepatocyte proliferation and gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Antiproliferative effect of rapamycin on growth factor-stimulated human adult lung fibroblasts in vitro may explain its superior efficacy for prevention and treatment of allograft obliterative airway disease in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin and FK506 binding proteins (immunophilins)

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin: Biological and therapeutic effects, binding by immunophilins and molecular targets of action

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

The immunophilins

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

A Putative Sirolimus (Rapamycin) Effector Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

A signaling pathway to translational control

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocyte. Evidence for inhibition of CREB/ATF binding activities

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

G1 phase progression: cycling on cue

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0009-9120%2898%2900045-9

7 January 2021

Identifiers

10.1016/S0009-9120(98)00045-9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9721431%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q57362835&oldid=2252913353"