The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (Q50545712)

15 March 2018

title

The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development (English)

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main subject

mesenchymal stem cell

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María L Toribio

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Pablo Menendez

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Rene Rodriguez

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author name string

R Rubio

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I Gutierrez-Aranda

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A I Sáez-Castillo

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M Rosu-Myles

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S Gonzalez-Garcia

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language of work or name

English

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publication date

10 December 2012

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published in

Oncogene

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volume

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issue

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page(s)

4970-4980

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Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.

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Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

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Rb regulates fate choice and lineage commitment in vivo

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pRb: master of differentiation. Coupling irreversible cell cycle withdrawal with induction of muscle-specific transcription.

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

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Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

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c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.

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Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma

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The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

31 March 2020

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Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

31 March 2020

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Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.507

Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.

31 March 2020

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Influence of the different CD34+ and CD34- cell subsets infused on clinical outcome after non-myeloablative allogeneic peripheral blood transplantation from human leucocyte antigen-identical sibling donors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2012.507

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.507

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15 March 2018

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15 March 2018