Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage (Q36954453)

17 August 2017

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage (English)

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17 August 2017

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metastatic osteosarcoma

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Mary L Bouxsein

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17 August 2017

Seth D Berman

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17 August 2017

Eliezer Calo

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17 August 2017

Allison S Landman

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17 August 2017

Paul S Danielian

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17 August 2017

Emily S Miller

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17 August 2017

Julie C West

1 reference

17 August 2017

Borel Djouedjong Fonhoue

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17 August 2017

Alicia Caron

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17 August 2017

Roderick Bronson

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17 August 2017

Siddhartha Mukherjee

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17 August 2017

Jacqueline A Lees

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17 August 2017

language of work or name

English

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publication date

12 August 2008

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Proceedings of the National Academy of Sciences of the United States of America

17 August 2017

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inferred from page(s)

published in

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17 August 2017

105

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17 August 2017

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17 August 2017

11851-11856

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The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

A review of clinical and molecular prognostic factors in osteosarcoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Mesenchymal stem cell features of Ewing tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Molecular pathogenesis of osteosarcoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Li-Fraumeni syndrome: a p53 family affair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Developmental defects and tumor predisposition in Rb mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

p53 and the Li-Fraumeni syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575280

Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

4 September 2018

1 reference

12 December 2020

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma

1 reference

12 December 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

12 December 2020

Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma

1 reference

12 December 2020

TP53Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study

1 reference

12 December 2020

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0805462105

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17 August 2017

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1 reference

17 August 2017

PubMed publication ID

18697945

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