checkpoint kinase 2 (Q5011104)

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mammalian protein found in Homo sapiens
  • hCds1
  • CHEK2
  • CHK2 checkpoint homolog
  • checkpoint-like protein CHK2
  • Hucds1
  • serine/threonine-protein kinase Chk2
  • cds1 homolog
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Language Label Description Also known as
English
checkpoint kinase 2
mammalian protein found in Homo sapiens
  • hCds1
  • CHEK2
  • CHK2 checkpoint homolog
  • checkpoint-like protein CHK2
  • Hucds1
  • serine/threonine-protein kinase Chk2
  • cds1 homolog

Statements

molecular function
protein serine/threonine kinase activity
determination method or standard
IDA
TAS
IEA
6 references
retrieved
27 February 2018
stated in
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
27 February 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
IEA
retrieved
27 February 2018
stated in
Chk2 activates E2F-1 in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
IDA
retrieved
27 February 2018
stated in
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O96017&geneProductId=UniProtKB:O96017
determination method or standard
IDA
protein binding
determination method or standard
IPI
17 references
retrieved
8 April 2019
stated in
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Per3, a circadian gene, is required for Chk2 activation in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic identification of molecular links between core and candidate genes in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
retrieved
8 April 2019
stated in
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IEA
retrieved
8 April 2019
stated in
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IDA
retrieved
8 April 2019
stated in
Chk2 activates E2F-1 in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IBA
cell component
biological process
cellular response to DNA damage stimulus
determination method or standard
IDA
TAS
IMP
IEA
5 references
retrieved
8 April 2019
stated in
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
8 April 2019
stated in
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
TAS
retrieved
8 April 2019
stated in
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O96017
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IEA
retrieved
8 April 2019
stated in
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O96017
determination method or standard
IDA
Gene Atlas image
PBB GE CHEK2 210416 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D064447
subject named as
Checkpoint Kinase 2
0 references
RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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