Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism (Q59607619)

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scientific article published on 02 August 2018

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English	Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism	scientific article published on 02 August 2018

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scholarly article

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Europe PubMed Central

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6168304

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15 April 2020

title

Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism (English)

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PMC publication ID

6168304

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15 April 2020

main subject

endocrinology

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obesity

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mitochondrion

1 reference

based on heuristic

inferred from title

preproinsulin

1 reference

based on heuristic

inferred from title

insulin resistance

1 reference

based on heuristic

inferred from title

author

Kenneth D'Souza

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1

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Europe PubMed Central

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6168304

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15 April 2020

Thomas O Eichmann

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6

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6168304

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15 April 2020

Vassilis Aidinis

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10

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6168304

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Thomas Pulinilkunnil

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12

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6168304

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Petra C Kienesberger

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13

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6168304

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author name string

Carine Nzirorera

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2

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6168304

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Andrew M Cowie

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3

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6168304

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15 April 2020

Geena P Varghese

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4

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6168304

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15 April 2020

Purvi Trivedi

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5

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6168304

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Dipsikha Biswas

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7

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6168304

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15 April 2020

Mohamed Touaibia

series ordinal

8

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6168304

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30072447%20AND%20SRC:MED&resulttype=core&format=json

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15 April 2020

Andrew J Morris

series ordinal

9

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6168304

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30072447%20AND%20SRC:MED&resulttype=core&format=json

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15 April 2020

Daniel A Kane

series ordinal

11

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6168304

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language of work or name

English

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publication date

2 August 2018

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6168304

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15 April 2020

published in

Journal of Lipid Research

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6168304

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15 April 2020

volume

59

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6168304

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issue

10

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6168304

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page(s)

1805-1817

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describes a project that uses

ImageJ

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11 June 2022

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Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity

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Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

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Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice

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Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

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Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis

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PF-8380 and closely related analogs: synthesis and structure-activity relationship towards autotaxin inhibition and glioma cell viability

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Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice.

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ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

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Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis.

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Promising pharmacological directions in the world of lysophosphatidic Acid signaling

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Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer

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inferred from PubMed ID database lookup

Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity.

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12 December 2020

based on heuristic

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Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

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based on heuristic

inferred from PubMed ID database lookup

Lysophospholipids in coronary artery and chronic ischemic heart disease

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12 December 2020

based on heuristic

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The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

1 reference

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https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autotaxin Is Regulated by Glucose and Insulin in Adipocytes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of optimal reference genes for quantitative real time PCR in muscle and adipose tissue for obesity and diabetes research

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30072447

retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1194/JLR.M082008

1 reference

stated in

Europe PubMed Central

PMC publication ID

6168304

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30072447%20AND%20SRC:MED&resulttype=core&format=json

retrieved

15 April 2020

PMC publication ID

6168304

1 reference

stated in

Europe PubMed Central

PMC publication ID

6168304

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30072447%20AND%20SRC:MED&resulttype=core&format=json

retrieved

15 April 2020

PubMed publication ID

30072447

1 reference

stated in

Europe PubMed Central

PMC publication ID

6168304

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30072447%20AND%20SRC:MED&resulttype=core&format=json

retrieved

15 April 2020

 

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