Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance. (Q52640499)

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21 March 2020

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26 August 2020

Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance (English)

1 reference

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21 March 2020

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cell surface receptor

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26 August 2020

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Geena Paramel Varghese

series ordinal

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21 March 2020

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21 March 2020

Kenneth D'Souza

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21 March 2020

language of work or name

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23 March 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29570618%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

26 August 2020

9 references

19 March 2019

24 March 2019

20 June 2019

31 July 2019

12 October 2019

19 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29570618%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

26 August 2020

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21 March 2020

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Creative Commons Attribution

21 March 2020

8 references

19 March 2019

24 March 2019

20 June 2019

31 July 2019

12 October 2019

19 November 2019

15 December 2019

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Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions.

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14 June 2018

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Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis

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Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

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14 June 2018

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Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis

14 June 2018

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Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice.

14 June 2018

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Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.

14 June 2018

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14 June 2018

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The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans

14 June 2018

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Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

14 June 2018

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Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice

14 June 2018

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14 June 2018

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14 June 2018

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Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

14 June 2018

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Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.

14 June 2018

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Effects of lysophosphatidic acid on the in vitro proliferation and differentiation of a novel porcine preadipocyte cell line

14 June 2018

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A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation

14 June 2018

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Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity

14 June 2018

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14 June 2018

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14 June 2018

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Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves

14 June 2018

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14 June 2018

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Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6

14 June 2018

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Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation

14 June 2018

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14 June 2018

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Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

14 June 2018

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Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo

14 June 2018

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Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis

14 June 2018

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14 June 2018

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Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake

14 June 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

14 June 2018

1 reference

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Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

14 June 2018

1 reference

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Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts

14 June 2018

1 reference

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IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells

14 June 2018

1 reference

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Lysophosphatidic acid mediates pleiotropic responses in skeletal muscle cells

14 June 2018

1 reference

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Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12.

14 June 2018

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Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.

14 June 2018

1 reference

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Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

14 June 2018

1 reference

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Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

14 June 2018

1 reference

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The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

14 June 2018

1 reference

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Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

14 June 2018

1 reference

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Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity

14 June 2018

1 reference

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

14 June 2018

1 reference

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The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

14 June 2018

1 reference

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PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth

14 June 2018

1 reference

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Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

14 June 2018

1 reference

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Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading

14 June 2018

1 reference

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Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile

14 June 2018

1 reference

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Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors

14 June 2018

1 reference

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Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

14 June 2018

1 reference

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

14 June 2018

1 reference

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic Acid Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury in the Immature Hearts of Rats

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Inflammation, cytokines and insulin resistance: a clinical perspective.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Associations of insulin resistance with cardiovascular risk factors and inflammatory cytokines in normal-weight Hispanic women

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid receptor mRNA levels in heart and white adipose tissue are associated with obesity in mice and humans.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Omental adipose tissue fibrosis and insulin resistance in severe obesity.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Alterations of plasma levels of lysophosphatidic acid in response to fasting of rats

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Lysophosphatidic acid protects mesenchymal stem cells against ischemia-induced apoptosis in vivo

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

LPA1 receptor activation promotes renal interstitial fibrosis

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Specific LPA receptor subtype mediation of LPA-induced hypertrophy of cardiac myocytes and involvement of Akt and NFkappaB signal pathways

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Serum lysophosphatidic acid is produced through diverse phospholipase pathways

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Relationship between obesity, insulin resistance, and coronary heart disease risk

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Plasma lysophosphatidic acid concentration and ovarian cancer

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factor-like lipids: distinct molecular species compositions

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5946184

Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid

13 August 2018

1 reference

12 December 2020

UCP1 deficiency increases susceptibility to diet-induced obesity with age

1 reference

12 December 2020

Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro: proposal of a plasma sample preparation method for laboratory testing of these lipids

1 reference

12 December 2020

Inflammation and insulin resistance

1 reference

12 December 2020

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans

1 reference

12 December 2020

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

1 reference

12 December 2020

Comparison of Lysophospholipid Levels in Rat Feces with Those in a Standard Chow

1 reference

12 December 2020

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

1 reference

12 December 2020

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

1 reference

12 December 2020

Depot-specific regulation of autotaxin with obesity in human adipose tissue

1 reference

12 December 2020

Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis

1 reference

12 December 2020

Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis

1 reference

12 December 2020

ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

1 reference

12 December 2020

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve

1 reference

12 December 2020

Identifiers

DOI

10.3390/NU10040399

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29570618%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29570618%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

29570618

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29570618%20AND%20SRC:MED&resulttype=core&format=json