Evaluating biological activity of compounds by transcription factor activity profiling (Q58695868)

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25 April 2020

title

Evaluating biological activity of compounds by transcription factor activity profiling (English)

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25 April 2020

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25 April 2020

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25 April 2020

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25 April 2020

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25 April 2020

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25 April 2020

Liubov Medvedeva

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25 April 2020

Elena Martsen

series ordinal

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25 April 2020

Ming Zeng

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language of work or name

English

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publication date

26 September 2018

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25 April 2020

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25 April 2020

volume

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issue

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25 April 2020

page(s)

eaar4666

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The Identification of Pivotal Transcriptional Factors Mediating Cell Responses To Drugs With Drug-Induced Liver Injury Liabilities

25 April 2020

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Mancozeb affects mitochondrial activity, redox status and ATP production in mouse granulosa cells

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30 November 2018

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Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

30 November 2018

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In vitro effects of cationic compounds on functional human sperm parameters

30 November 2018

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Preferential binding of insecticide phorate with sub-domain IIA of human serum albumin induces protein damage and its toxicological significance.

30 November 2018

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The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria.

30 November 2018

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Identification of small molecules enhancing autophagic function from drug network analysis

30 November 2018

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Genotoxic fungicide methyl thiophanate as an oxidative stressor inducing 8-oxo-7,8-dihydro-2' -deoxyguanosine adducts in DNA and mutagenesis

30 November 2018

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Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

30 November 2018

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Mitochondrial energy metabolism impairment and liver dysfunction following chronic exposure to dichlorvos

30 November 2018

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The proteasome is a molecular target of environmental toxic organotins

30 November 2018

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

30 November 2018

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Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.

30 November 2018

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Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors.

30 November 2018

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Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

30 November 2018

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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

30 November 2018

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Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer.

30 November 2018

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Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

30 November 2018

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Wnt signalling and the actin cytoskeleton

30 November 2018

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An inherent role of microtubule network in the action of nuclear receptor

30 November 2018

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

30 November 2018

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Mitochondrial retrograde signaling

30 November 2018

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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

30 November 2018

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Two critical factors affecting the release of mitochondrial cytochrome C as revealed by studies using N,N'-dicyclohexylcarbodiimide as an atypical inducer of permeability transition

30 November 2018

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Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram

30 November 2018

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Ontological analysis of gene expression data: current tools, limitations, and open problems

30 November 2018

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Idiosyncratic drug hepatotoxicity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Clinical development of histone deacetylase inhibitors as anticancer agents

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Effects of the carbamates fenoxycarb, propamocarb and propoxur on energy supply, glucose utilization and SH-groups in neurons

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

In vitro effect of eugenol and cinnamaldehyde on membrane potential and respiratory chain complexes in isolated rat liver mitochondria

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

AP-1 as a regulator of cell life and death

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Hepatotoxicity with thiazolidinediones: is it a class effect?

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Sensitivity of mitochondrial respiration to different inhibitors in Venturia inaequalis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Ethylazinphos interaction with membrane lipid organization induces increase of proton permeability and impairment of mitochondrial bioenergetic functions.

30 November 2018

1 reference

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Lessons from the glitazones: a story of drug development

30 November 2018

1 reference

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Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone

30 November 2018

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Microtubules and signal transduction

30 November 2018

1 reference

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p53, the cellular gatekeeper for growth and division

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen

30 November 2018

1 reference

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Mitochondrial toxicity of phthalate esters

30 November 2018

1 reference

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Proton translocation in membranes of submitochondrial particles

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6157966

Effect of benomyl and thiophanate-methyl on metabolic activities of Rhizoctonia solani Kühn

30 November 2018

1 reference

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Nitrofurantoin inhibition of mouse liver mitochondrial respiration involving NAD-linked substrates

30 November 2018

1 reference

12 December 2020

Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction

1 reference

12 December 2020

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

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Proteasome inhibition leads to the activation of all members of the heat-shock-factor family

1 reference

12 December 2020

Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions

1 reference

12 December 2020

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

12 December 2020

In vitro alachlor effects on reactive oxygen species generation, motility patterns and apoptosis markers in human spermatozoa

1 reference

12 December 2020

Discovery of drug mode of action and drug repositioning from transcriptional responses

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12 December 2020

Identifiers

DOI

10.1126/SCIADV.AAR4666

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30263952%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30263952%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

PubMed publication ID

30263952

1 reference

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