Idiosyncratic drug hepatotoxicity (Q36148442)

12 August 2017

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title

Idiosyncratic drug hepatotoxicity (English)

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12 August 2017

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Neil Kaplowitz

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12 August 2017

publication date

1 June 2005

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Nature Reviews Drug Discovery

12 August 2017

published in

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

489-499

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Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

12 August 2017

cites work

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Drug-induced liver disorders: implications for drug development and regulation

21 January 2018

1 reference

Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury

21 January 2018

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Inflammatory mechanisms in childhood asthma

21 January 2018

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Clinical perspectives on xenobiotic-induced hepatotoxicity

21 January 2018

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The danger hypothesis applied to idiosyncratic drug reactions

21 January 2018

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Halothane-induced hepatic disease

21 January 2018

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Troglitazone-induced liver failure: a case study

21 January 2018

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Defining patient risks from expanded preventive therapies

21 January 2018

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Tolerance, danger, and the extended family

21 January 2018

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Role of viral infections in the induction of adverse drug reactions

21 January 2018

1 reference

Antituberculosis drug-induced hepatotoxicity. The role of hepatitis C virus and the human immunodeficiency virus

21 January 2018

1 reference

Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial

21 January 2018

1 reference

Biochemical changes and morphological alterations of the liver in guinea-pigs after administration of simvastatin (HMG CoA reductase-inhibitor).

21 January 2018

1 reference

Troglitazone and liver injury: in search of answers

21 January 2018

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Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus

21 January 2018

1 reference

Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid

21 January 2018

1 reference

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

1 reference

Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity

21 January 2018

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Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.

21 January 2018

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Role of MRP2 and GSH in intrahepatic cycling of toxins

21 January 2018

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Hepatotoxicity of psychotropic drugs

21 January 2018

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HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease

21 January 2018

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Tacrine. A cause of fatal hepatotoxicity?

21 January 2018

1 reference

Hepatic findings in long-term clinical trials of ximelagatran

21 January 2018

1 reference

Isoniazid-associated hepatitis deaths: a review of available information

21 January 2018

1 reference

Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment

21 January 2018

1 reference

A study of compliance with FDA recommendations for pemoline (Cylert).

21 January 2018

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Liver enzyme monitoring in patients treated with troglitazone

21 January 2018

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Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

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Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression

21 January 2018

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Database development in toxicogenomics: issues and efforts

21 January 2018

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Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project

21 January 2018

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Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat.

21 January 2018

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Toxic effect of troglitazone on cultured rat hepatocytes

21 January 2018

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Effects of troglitazone on HepG2 viability and mitochondrial function

21 January 2018

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Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors

21 January 2018

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Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury

21 January 2018

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Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.

21 January 2018

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

21 January 2018

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An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

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A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury.

21 January 2018

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Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

21 January 2018

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Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

21 January 2018

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Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease

21 January 2018

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Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next?

21 January 2018

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Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes

21 January 2018

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Mechanisms of liver cell injury

21 January 2018

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Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

21 January 2018

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Immune mechanisms in tienilic acid associated hepatotoxicity

21 January 2018

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Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

21 January 2018

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A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

21 January 2018

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Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.

21 January 2018

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Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity

21 January 2018

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Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis

21 January 2018

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Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity

21 January 2018

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Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

21 January 2018

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Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

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IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes

21 January 2018

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Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity

21 January 2018

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Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice

21 January 2018

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A protective role for cyclooxygenase-2 in drug-induced liver injury in mice

21 January 2018

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Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice

21 January 2018

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Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2

21 January 2018

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Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury

21 January 2018

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Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice

21 January 2018

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Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

21 January 2018

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Antituberculosis drug-related liver dysfunction in chronic hepatitis B infection

21 January 2018

1 reference

Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients

21 January 2018

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Hepatic dysfunction associated with troglitazone

31 March 2020

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Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic

31 March 2020

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Role of CYP2E1 in the hepatotoxicity of acetaminophen

31 March 2020

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Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages

31 March 2020

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Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors

31 March 2020

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Erythromycin-associated cholestatic hepatitis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1750

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12 August 2017

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