Chapter 4.4 The glutamatergic system as a potential therapeutic target for the treatment of anxiety disorders

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7 January 2021

The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse

1 reference

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7 January 2021

(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors

1 reference

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7 January 2021

In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

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7 January 2021

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism.

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7 January 2021

Cost of disorders of the brain in Europe

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7 January 2021

Anxiolytic-like effects of N-methyl-D-aspartate-associated glycine receptor ligands in the rat potentiated startle test

1 reference

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7 January 2021

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition

1 reference

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7 January 2021

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

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7 January 2021

Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats

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7 January 2021

A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors

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7 January 2021

Fear extinction in rodents: basic insight to clinical promise

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7 January 2021

Stress-induced changes in messenger RNA levels of N-methyl-D-aspartate and AMPA receptor subunits in selected regions of the rat hippocampus and hypothalamus

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7 January 2021

Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia

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7 January 2021

Measuring normal and pathological anxiety-like behaviour in mice: a review.

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7 January 2021

Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.

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7 January 2021

Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740.

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7 January 2021

Glutamate and anxiety

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7 January 2021

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.

1 reference

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7 January 2021

Review: neurotransmitter receptors. II. AMPA and kainate receptors

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7 January 2021

Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

1 reference

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7 January 2021

Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice

1 reference

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7 January 2021

Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems

1 reference

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7 January 2021

Reduced stress-induced hyperthermia in mGluR5 knockout mice

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7 January 2021

Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

1 reference

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7 January 2021

Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors

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7 January 2021

Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice

1 reference

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7 January 2021

Calcium permeability of glutamate-gated channels in the central nervous system

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7 January 2021

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

1 reference

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7 January 2021

Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice

1 reference

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7 January 2021

The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

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7 January 2021

Activity-dependent decrease in NMDA receptor responses during development of the visual cortex

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7 January 2021

Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268

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7 January 2021

Regulation of neurotransmitter release by metabotropic glutamate receptors

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7 January 2021

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

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7 January 2021

The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats

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7 January 2021

In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.

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7 January 2021

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

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7 January 2021

Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801.

1 reference

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7 January 2021

(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity

1 reference

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7 January 2021

Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial

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7 January 2021

The role of glutamate in anxiety and related disorders

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7 January 2021

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

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7 January 2021

N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons

1 reference

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7 January 2021

The ascent of mouse: advances in modelling human depression and anxiety

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7 January 2021

Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

1 reference

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7 January 2021

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

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7 January 2021

Emerging use of non-viral RNA interference in the brain

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7 January 2021

Analogues of Glutamic and γ-Amino-n-butyric acids having Potent Actions on Mammalian Neurones

1 reference

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7 January 2021

Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect

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7 January 2021

Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy

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7 January 2021

Effects of D-cycloserine on extinction: translation from preclinical to clinical work

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7 January 2021

Glutamate-receptor-mediated encoding and retrieval of paired-associate learning

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7 January 2021

AMPA receptor antagonists as potential anticonvulsant drugs

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7 January 2021

NR2C by NR2B subunit exchange in juvenile mice affects emotionality and 5-HT in the frontal cortex.

1 reference

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7 January 2021

Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic

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7 January 2021

NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice

1 reference

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7 January 2021

Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus

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7 January 2021

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

1 reference

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7 January 2021

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

1 reference

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7 January 2021

New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons

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7 January 2021

Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors

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7 January 2021

Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8

1 reference

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7 January 2021

Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala

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7 January 2021

N-Methyl-D-Aspartate Treatment Increases Circulating Adrenocorticotropin and Luteinizing Hormone in the Rat*

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7 January 2021

The neuroanatomical and neurochemical basis of conditioned fear.

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7 January 2021

Metabotropic glutamate receptors.

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7 January 2021

Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: effects of diazepam

1 reference

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7 January 2021

Genetic animal models of anxiety

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7 January 2021

Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents.

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7 January 2021

Glutamate- and GABA-based CNS therapeutics

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7 January 2021

Interactions between ifenprodil and dizocilpine on mouse behaviour in models of anxiety and working memory

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7 January 2021

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

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7 January 2021

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

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7 January 2021

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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7 January 2021

Second-order fear conditioning prevented by blocking NMDA receptors in amygdala

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7 January 2021

Emotional learning and glutamate: translational perspectives

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7 January 2021

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

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7 January 2021

Glutamate-based therapeutic approaches: NR2B receptor antagonists

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7 January 2021

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

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7 January 2021

Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey

1 reference

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7 January 2021

Kainate-binding proteins: phylogeny, structures and possible functions

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7 January 2021

Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse

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7 January 2021

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

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7 January 2021

ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies

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7 January 2021

Psychiatric drugs. Excited by glutamate

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7 January 2021

Cloned glutamate receptors

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7 January 2021

Cloning by functional expression of a member of the glutamate receptor family

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7 January 2021

Targeted gene mutation approaches to the study of anxiety-like behavior in mice

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7 January 2021

Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes

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7 January 2021

Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release

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7 January 2021

Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice.

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7 January 2021

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

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7 January 2021

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

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7 January 2021

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

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7 January 2021

Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord

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7 January 2021

Structural and biochemical views of metabotropic glutamate receptor activation

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7 January 2021

Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro

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7 January 2021

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

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7 January 2021

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).

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7 January 2021

Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268.

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7 January 2021

Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists

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7 January 2021

Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors.

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7 January 2021

Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp.

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7 January 2021

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

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7 January 2021

A family of AMPA-selective glutamate receptors

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7 January 2021

Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

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7 January 2021

NMDA receptor pathways as drug targets

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7 January 2021

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

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7 January 2021

Ionotropic and metabotropic glutamate receptor structure and pharmacology

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7 January 2021

Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site

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7 January 2021

Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle

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7 January 2021

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

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7 January 2021

Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A

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7 January 2021

Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit

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7 January 2021

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

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7 January 2021

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling

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7 January 2021

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

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7 January 2021

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

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7 January 2021

Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: Evaluation of N-methyl-d-aspartate antagonists

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7 January 2021

The putative AMPA receptor antagonist, LY326325, produces anxiolytic-like effects without altering locomotor activity in rats

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7 January 2021

A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area

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7 January 2021

Beyond monoamines: glutamatergic function in mood disorders

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7 January 2021

D-cycloserine augmented exposure therapy for obsessive-compulsive disorder

1 reference

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7 January 2021

Fear and anxiety: animal models and human cognitive psychophysiology

1 reference

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7 January 2021

D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Emotion circuits in the brain

1 reference

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7 January 2021

Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Molecular physiology of kainate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effect of MS-153 on the acquisition and expression of conditioned fear in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Rat 22kHz ultrasonic vocalizations as alarm cries

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

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7 January 2021

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Long-term potentiation in the amygdala: a mechanism for emotional learning and memory.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Neurobiology of Pavlovian fear conditioning.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Antagonism of non-NMDA receptors in the dorsal periaqueductal grey induces anxiolytic effect in the elevated plus maze

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Open-label trial of riluzole in generalized anxiety disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

AMPA receptor GluR2, but not GluR1, subunit deletion impairs emotional response conditioning in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Intra-septal infusions of excitatory amino acid receptor antagonists have differential effects in two animal models of anxiety

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The neurobiology and control of anxious states

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The Vogel conflict test: procedural aspects, gamma-aminobutyric acid, glutamate and monoamines

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like effects of AP7 injected into the dorsolateral or ventrolateral columns of the periaqueductal gray of rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Close linkage between calcium/calmodulin kinase II alpha/beta and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Mechanisms of fear extinction

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Molecular diversity and functions of glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Stress-induced hyperthermia: effects of acute and repeated dosing of MPEP.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glutamate receptors in the mammalian central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

MK-801 stimulates the release of adrenocorticotrophin but not does affect the release of prolactin in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Precision in mouse behavior genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Contributions of the amygdala to emotion processing: from animal models to human behavior

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Ketamine administration disturbs behavioural and distributed neural correlates of fear conditioning in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The metabotropic glutamate receptors: structure and functions

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of antagonists at the NMDA receptor complex in two models of anxiety.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Antidepressant- and anxiolytic-like activity of magnesium in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Tolerance to anxiolytic- and antidepressant-like effects of a partial agonist of glycineB receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Both mGluR1 and mGluR5 mediate Ca2+ release and inward currents in hippocampal CA1 pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glutamate receptor function in learning and memory

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Animal models of ??anxiety??: where next?

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Animal models of anxiety: an ethological perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Fear conditioning induces associative long-term potentiation in the amygdala

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of single or repeated restraint stress on GluR1 and GluR2 flip and flop mRNA expression in the hippocampal formation.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Excitatory amino acid receptors in the basolateral amygdala regulate anxiety responses in the social interaction test

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Altered anxiety-related responses in mutant mice lacking the beta4 subunit of the nicotinic receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Stress-induced vocalisation in adult animals. A valid model of anxiety?

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The psychobiology of anxiolytic drugs. Part 1: Basic neurobiology

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Modulation of Multiple Potassium Currents by Metabotropic Glutamate Receptors in Neurons of the Hypothalamic Supraoptic Nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The role of RNA editing in controlling glutamate receptor channel properties.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders

1 reference

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7 January 2021

Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like activity of MGS0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behavior test

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Advances in the treatment of anxiety: targeting glutamate

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7 January 2021

Corticotropin-releasing factor modulates basal and stress-induced excitatory amino acid release in the locus coeruleus of conscious rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Glutamate receptor channels: novel properties and new clones

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

mGlu5 receptor antagonists: a novel class of anxiolytics?

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Corticotropin-releasing factor receptor 1 and central heart rate regulation in mice during expression of conditioned fear

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Riluzole antagonizes the anxiogenic properties of the beta-carboline FG 7142 in rats

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Genetic enhancement of learning and memory in mice

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The genes and brains of mice and men.

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Interfering with the brain: use of RNA interference for understanding the pathophysiology of psychiatric and neurological disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

A simple and reliable conflict procedure for testing anti-anxiety agents

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Are fear memories made and maintained by the same NMDA receptor-dependent mechanisms?

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of modulation of NMDA neurotransmission on response rate and duration in a conflict procedure in rats

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Antipunishment effects of acute and repeated administration of phencyclidine and NPC 12626 in rats

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https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Differential control of glucoregulatory hormone response and glucose metabolism by NMDA and kainate.

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

Pre- and posttraining infusion of N-methyl-D-aspartate receptor antagonists into the amygdala impair memory in an inhibitory avoidance task

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021

N-methyl-D-aspartate lesions of the lateral and basolateral nuclei of the amygdala block fear-potentiated startle and shock sensitization of startle

1 reference

https://api.crossref.org/works/10.1016%2FS1569-7339%2807%2900013-6

7 January 2021