In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders (Q34493370)

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English	In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

author name string

Andrew Alt

1

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Europe PubMed Central

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2 August 2017

Brianne Weiss

2

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Europe PubMed Central

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2 August 2017

Ann Marie Ogden

3

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Europe PubMed Central

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2 August 2017

Xia Li

4

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Europe PubMed Central

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2 August 2017

Scott D Gleason

5

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Europe PubMed Central

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2 August 2017

David O Calligaro

6

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2 August 2017

David Bleakman

7

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Europe PubMed Central

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2 August 2017

Jeffrey M Witkin

8

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2 August 2017

language of work or name

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inferred from title

publication date

10 February 2006

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Europe PubMed Central

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2 August 2017

Psychopharmacology

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2 August 2017

185

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Europe PubMed Central

PubMed publication ID

2 August 2017

2

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Europe PubMed Central

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2 August 2017

240-247

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Europe PubMed Central

PubMed publication ID

2 August 2017

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

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Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular targets in the treatment of anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an anxiogenic action of AMPA receptor antagonists in the plus-maze test

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

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inferred from PubMed ID database lookup

RELATIVE POTENCIES OF BENZODIAZEPINES AS MEASURED BY THEIR EFFECTS ON CONFLICT BEHAVIOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the 2-amino-3-hydroxy-5-methyl-4-isoxazole-proprionic acid/kainate antagonist LY293558 on spontaneous and evoked postoperative pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of the specificity of behavioral effects of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of glutamate receptors: strategies for the development of novel antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the appetite stimulant chlordimeform on food and water consumption of rats: comparison with chlordiazepoxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate receptor ligands as anxiolytics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Migraine and psychiatric comorbidity: from theory and hypotheses to clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of pain by anxiety is associated with activity in a hippocampal network.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregabalin (Pfizer)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The putative AMPA receptor antagonist, LY326325, produces anxiolytic-like effects without altering locomotor activity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipunishment effects of acute and repeated administration of phencyclidine and NPC 12626 in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some behavioral effects of AMPA/kainate receptor agonist and antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the binding of [3H]muscimol, a potent gamma-aminobutyric acid agonist, to rat brain synaptosomal membranes using a filtration assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartic acid-induced lethality in mice: selective antagonism by phencyclidine-like drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of psychotropic drugs on food reinforced behavior and on food consumption

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective expression of heteromeric AMPA receptors driven by flip-flop differences

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate receptor-mediated heterosynaptic facilitation in the amygdala

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate in CNS disorders as a target for drug development: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/16470401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-005-0292-0

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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