Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney (Q56967272)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29925518%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney (English)

1 reference

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1 April 2020

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1 April 2020

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1 April 2020

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1 April 2020

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1 April 2020

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1 April 2020

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1 April 2020

Melanie Boerries

1 reference

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1 April 2020

Amandine Viau

1 reference

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1 April 2020

Frank Bienaimé

1 reference

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1 April 2020

Kamile Lukas

1 reference

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1 April 2020

Abhijeet P Todkar

1 reference

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1 April 2020

Manuel Knoll

1 reference

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1 April 2020

Oliver Kretz

1 reference

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1 April 2020

Martin Helmstädter

1 reference

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1 April 2020

Wilfried Reichardt

1 reference

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1 April 2020

Simone Braeg

1 reference

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1 April 2020

Tom Aschman

1 reference

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1 April 2020

Annette Merkle

1 reference

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1 April 2020

Dietmar Pfeifer

1 reference

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1 April 2020

Verónica I Dumit

1 reference

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1 April 2020

Marie-Claire Gubler

1 reference

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1 April 2020

Roland Nitschke

1 reference

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1 April 2020

Tobias B Huber

1 reference

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1 April 2020

Fabiola Terzi

1 reference

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1 April 2020

Florian Grahammer

1 reference

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1 April 2020

Gerd Walz

1 reference

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1 April 2020

Antigoni Triantafyllopoulou

1 reference

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1 April 2020

language of work or name

English

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publication date

19 June 2018

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1 April 2020

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volume

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issue

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describes a project that uses

1 April 2020

page(s)

e98615

0 references

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6068446

based on heuristic

inferred from PubMed Central ID database lookup

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2 November 2018

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LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

2 November 2018

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2 November 2018

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Anks3 alters the sub-cellular localization of the Nek7 kinase

2 November 2018

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2 November 2018

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Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

2 November 2018

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Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

2 November 2018

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2 November 2018

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2 November 2018

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Anks3 interacts with nephronophthisis proteins and is required for normal renal development

2 November 2018

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2 November 2018

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limma powers differential expression analyses for RNA-sequencing and microarray studies

2 November 2018

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The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin

2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

2 November 2018

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ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

2 November 2018

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2 November 2018

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Identification of 99 novel mutations in a worldwide cohort of 1,056 patients with a nephronophthisis-related ciliopathy

2 November 2018

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Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

2 November 2018

1 reference

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Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

2 November 2018

1 reference

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Cilia functions in development

2 November 2018

1 reference

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Macrophages promote cyst growth in polycystic kidney disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD).

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

2 November 2018

1 reference

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Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

2 November 2018

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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

2 November 2018

1 reference

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Primary cilia regulate mTORC1 activity and cell size through Lkb1.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

A framework for oligonucleotide microarray preprocessing.

2 November 2018

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Everolimus in patients with autosomal dominant polycystic kidney disease.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels

2 November 2018

1 reference

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2 November 2018

1 reference

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Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

2 November 2018

1 reference

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Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts

2 November 2018

1 reference

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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

2 November 2018

1 reference

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Somatic LKB1 mutations promote cervical cancer progression

2 November 2018

1 reference

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Collective cell migration drives morphogenesis of the kidney nephron

2 November 2018

1 reference

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Nutrient sensing and inflammation in metabolic diseases

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

VEGF inhibition and renal thrombotic microangiopathy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Ciliary proteins link basal body polarization to planar cell polarity regulation

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

LKB1 modulates lung cancer differentiation and metastasis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Using GOstats to test gene lists for GO term association

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Vertebrate Smoothened functions at the primary cilium

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Urinary Excretion of Monocyte Chemoattractant Protein-1 in Autosomal Dominant Polycystic Kidney Disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Bending the MDCK cell primary cilium increases intracellular calcium

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6068446

Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29925518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29925518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201798615

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29925518%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29925518%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

29925518

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29925518%20AND%20SRC:MED&resulttype=core&format=json