Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells (Q34690043)

4 August 2017

title

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells (English)

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4 August 2017

Thomas L Saunders

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Sean J Morrison

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Daisuke Nakada

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4 August 2017

language of work or name

English

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publication date

1 December 2010

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4 August 2017

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4 August 2017

volume

468

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4 August 2017

issue

7324

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4 August 2017

page(s)

653-658

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The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

4 August 2017

cites work

1 reference

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LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

7 July 2018

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LKB1 regulates pancreatic beta cell size, polarity, and function

7 July 2018

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

7 July 2018

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

7 July 2018

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

7 July 2018

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Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

7 July 2018

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 July 2018

1 reference

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

7 July 2018

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Lkb1 deficiency causes prostate neoplasia in the mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

7 July 2018

1 reference

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Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

7 July 2018

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 July 2018

1 reference

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

7 July 2018

1 reference

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Energy-dependent regulation of cell structure by AMP-activated protein kinase

7 July 2018

1 reference

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LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

LKB1-dependent signaling pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

TSC2 mediates cellular energy response to control cell growth and survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

A highly efficient recombineering-based method for generating conditional knockout mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Inducible gene targeting in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059717

26 October 2018

Identifiers

DOI

10.1038/NATURE09571

1 reference

Dimensions Publication ID

4 August 2017

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1 reference

4 August 2017

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