MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency (Q56965940)

object named as

Joachim Spranger

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Patrick Scheerer

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Ulrike Blume-Peytavi

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author name string

Heike Biebermann

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I Sadaf Farooqi

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Lex Van der Ploeg

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Barbara Wolters

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Christine Poitou

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Lia Puder

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Fred Fiedorek

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Keith Gottesdiener

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Gunnar Kleinau

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Nicolas Heyder

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Patrick Scheerer

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Irina Jahnke

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Shubh Sharma

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Jacek Mokrosinski

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Susanna Wiegand

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Anne Müller

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Katja Weiß

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Knut Mai

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Annette Grüters

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Oliver Blankenstein

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Heiko Krude

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Peter Kühnen

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I. Sadaf Farooqi

20 years of leptin: human disorders of leptin action

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language of work or name

English

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publication date

May 2018

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551-555

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cites work

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Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Investigational drugs in Phase II clinical trials for the treatment of obesity: implications for future development of novel therapies

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Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

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Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

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Seven novel deleterious LEPR mutations found in early-onset obesity: a ΔExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect

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Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist

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7 January 2021

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

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G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

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Biased signaling at neural melanocortin receptors in regulation of energy homeostasis

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G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins

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Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

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Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist

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Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

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3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling

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7 January 2021

Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity

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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

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Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.

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Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

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12 December 2020