An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C) (Q56788667)

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Peter Chase

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Christina Eberhart

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Edward A. Salter

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Brandon D’Arcy

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Chad E. Schroeder

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Andrzej Wierzbicki

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Peter Hodder

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Richard E. Honkanen

Protein phosphatases in pancreatic islets.

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publication date

27 September 2016

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volume

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issue

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page(s)

21-31

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cites work

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

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Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors

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Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).

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