Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C). (Q35406908)

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English	Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C). (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

author name string

Mark R Swingle

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Richard E Honkanen

2

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Europe PubMed Central

PubMed publication ID

8 August 2017

publication date

1 October 2014

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Europe PubMed Central

PubMed publication ID

8 August 2017

Assay and Drug Development Technologies

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Europe PubMed Central

PubMed publication ID

8 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

481-496

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins

1 reference

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12 July 2018

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain

1 reference

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Calcineurin inhibitors: 40 years later, can't live without ...

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The ability to enhance the solubility of its fusion partners is an intrinsic property of maltose-binding protein but their folding is either spontaneous or chaperone-mediated

1 reference

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The therapeutic target Hsp90 and cancer hallmarks

1 reference

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12 July 2018

The PP1 binding code: a molecular-lego strategy that governs specificity

1 reference

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12 July 2018

Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5

1 reference

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12 July 2018

The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease.

1 reference

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12 July 2018

Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors

1 reference

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12 July 2018

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

1 reference

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12 July 2018

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

1 reference

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12 July 2018

Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme

1 reference

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The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

1 reference

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Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.

1 reference

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12 July 2018

Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer

1 reference

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12 July 2018

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

1 reference

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12 July 2018

High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors

1 reference

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12 July 2018

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

1 reference

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12 July 2018

Development and optimization of high-throughput in vitro protein phosphatase screening assays

1 reference

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12 July 2018

Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse

1 reference

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12 July 2018

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4229695

12 July 2018

Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade

1 reference

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12 July 2018

A homogeneous, nonradioactive high-throughput fluorogenic protein phosphatase assay

1 reference

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12 July 2018

DNA-PKcs function regulated specifically by protein phosphatase 5

1 reference

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12 July 2018

Functional diversity of protein phosphatase-1, a cellular economizer and reset button

1 reference

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12 July 2018

A specific mechanism of nonspecific inhibition

1 reference

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The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

1 reference

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Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

1 reference

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12 July 2018

Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity

1 reference

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Protein phosphatase 1--targeted in many directions

1 reference

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12 July 2018

Protein phosphatase 1 regulation by inhibitors and targeting subunits

1 reference

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12 July 2018

The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

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12 July 2018

Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest

1 reference

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Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.

1 reference

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Novel protein serine/threonine phosphatases: Variety is the spice of life

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Kinetic analysis of the catalytic domain of human cdc25B.

1 reference

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Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor

1 reference

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Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.

1 reference

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Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH

1 reference

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Expression of the catalytic subunit of phosphorylase phosphatase (protein phosphatase-1) in Escherichia coli

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Aggregating behavior of phenolic compounds--a source of false bioassay results?

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Serine/threonine protein phosphatase assays

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Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.

1 reference

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Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days

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Identification of potential physiological activators of protein phosphatase 5.

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Identifiers

10.1089/ADT.2014.603

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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