Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease. (Q55240777)

http://europepmc.org/abstract/PMC/5926497

28 June 2018

6 references

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8 October 2022

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease. (English)

1 reference

http://europepmc.org/abstract/PMC/5926497

28 June 2018

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proteostasis deficiency

6 references

25 April 2019

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8 October 2022

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12 September 2019

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Parkinson disease associated proteins

1 reference

20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Veerle Baekelandt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

1 reference

16 April 2018

7 references

http://europepmc.org/abstract/PMC/5926497

28 June 2018

25 April 2019

12 September 2019

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19 December 2019

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8 October 2022

Journal of Immunology Research

7 references

25 April 2019

12 September 2019

12 October 2019

19 December 2019

20 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

8 October 2022

2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

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Creative Commons Attribution 4.0 International

1 June 2020

6 references

25 April 2019

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on focus list of Wikimedia project

8 October 2022

copyrighted

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ScienceSource

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cites work

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Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

30 June 2018

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

30 June 2018

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30 June 2018

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FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease

30 June 2018

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Gut microbiota are related to Parkinson's disease and clinical phenotype

30 June 2018

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30 June 2018

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30 June 2018

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Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials

30 June 2018

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Association of Parkinson disease with structural and regulatory variants in the HLA region

30 June 2018

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Structural and functional characterization of two alpha-synuclein strains

30 June 2018

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α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model

30 June 2018

1 reference

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A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease

30 June 2018

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CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease

30 June 2018

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

30 June 2018

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Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

30 June 2018

1 reference

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

30 June 2018

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Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

30 June 2018

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LRRK2 inhibition attenuates microglial inflammatory responses

30 June 2018

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Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease

30 June 2018

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30 June 2018

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Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

30 June 2018

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α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.

30 June 2018

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Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

30 June 2018

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Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes

30 June 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

30 June 2018

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Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease

30 June 2018

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

30 June 2018

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Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

30 June 2018

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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

30 June 2018

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Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

30 June 2018

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Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.

30 June 2018

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

30 June 2018

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Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

30 June 2018

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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

30 June 2018

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A timeline for Parkinson's disease

30 June 2018

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Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

30 June 2018

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

30 June 2018

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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

30 June 2018

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Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease

30 June 2018

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Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

30 June 2018

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Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

30 June 2018

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Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons

30 June 2018

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Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease

30 June 2018

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Synuclein activates microglia in a model of Parkinson's disease

30 June 2018

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30 June 2018

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

30 June 2018

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

30 June 2018

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S100B binding to RAGE in microglia stimulates COX-2 expression

30 June 2018

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Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease

30 June 2018

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Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease

30 June 2018

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30 June 2018

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Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

30 June 2018

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

30 June 2018

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Stages in the development of Parkinson's disease-related pathology

30 June 2018

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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

30 June 2018

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Immune system and peripheral nerves in propagation of prions to CNS.

30 June 2018

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Staging of brain pathology related to sporadic Parkinson's disease

30 June 2018

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Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism

30 June 2018

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α-Synuclein in Lewy bodies

30 June 2018

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

30 June 2018

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Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

30 June 2018

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Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology

30 June 2018

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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.

30 June 2018

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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.

13 August 2018

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Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson's disease.

13 August 2018

1 reference

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IL-6 serum levels are elevated in Parkinson's disease patients with fatigue compared to patients without fatigue.

13 August 2018

1 reference

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Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

13 August 2018

1 reference

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Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

13 August 2018

1 reference

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Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

13 August 2018

1 reference

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Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease

13 August 2018

1 reference

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Association of the human leucocyte antigen region with susceptibility to Parkinson's disease

13 August 2018

1 reference

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Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils

13 August 2018

1 reference

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CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease.

13 August 2018

1 reference

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Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism

13 August 2018

1 reference

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A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway.

13 August 2018

1 reference

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Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

A possible role for humoral immunity in the pathogenesis of Parkinson's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Clinical trials. Halt of Celebrex study threatens drug's future, other trials

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Glutathione peroxidase, glial cells and Parkinson's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926497

Microglial response to 6-hydroxydopamine-induced substantia nigra lesions

29 September 2018

1 reference

12 December 2020

Transforming growth factor-beta 1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease

1 reference

12 December 2020

Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

1 reference

12 December 2020

Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats

1 reference

12 December 2020

[Immune factors or depression? Fatigue correlates in Parkinson's disease]

1 reference

12 December 2020

Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression

1 reference

12 December 2020

Parkinson’s disease is associated with increased serum levels of macrophage migration inhibitory factor

1 reference

12 December 2020

Identifiers

DOI

10.1155/2018/4784268

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

29850629

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29850629%20AND%20SRC:MED&resulttype=core&format=json