Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway. (Q55249441)

29 June 2018

title

Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway. (English)

1 reference

29 June 2018

author name string

Dengliang Huang

1 reference

29 June 2018

Yiting Wang

1 reference

29 June 2018

Jiabin Tang

1 reference

29 June 2018

Shiwen Luo

1 reference

29 June 2018

publication date

1 March 2018

1 reference

29 June 2018

published in

Oncology Letters

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29 June 2018

volume

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29 June 2018

issue

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29 June 2018

page(s)

6077-6086

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29 June 2018

Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway

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30 June 2018

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30 June 2018

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microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)

30 June 2018

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Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

30 June 2018

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Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells

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30 June 2018

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BCC or not: Sufu keeps it in check

30 June 2018

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The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation

30 June 2018

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Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations

30 June 2018

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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

30 June 2018

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Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis

30 June 2018

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Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors

30 June 2018

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SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.

30 June 2018

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Canonical and non-canonical Hedgehog signalling and the control of metabolism

30 June 2018

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Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila

30 June 2018

1 reference

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A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling

30 June 2018

1 reference

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Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation

30 June 2018

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Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

30 June 2018

1 reference

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Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma

30 June 2018

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Hedgehog signaling pathway and ovarian cancer

30 June 2018

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The mechanisms of Hedgehog signalling and its roles in development and disease

30 June 2018

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Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

30 June 2018

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Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

30 June 2018

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Loss of SUFU function in familial multiple meningioma.

30 June 2018

1 reference

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Hedgehog signaling regulates bladder cancer growth and tumorigenicity

30 June 2018

1 reference

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High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7.

30 June 2018

1 reference

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Hedgehog signaling regulates nociceptive sensitization.

30 June 2018

1 reference

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Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Gli proteins in development and disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mechanisms and functions of Hedgehog signalling across the metazoa

30 June 2018

1 reference

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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The primary cilium: a signalling centre during vertebrate development

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli

30 June 2018

1 reference

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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

30 June 2018

1 reference

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The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

30 June 2018

1 reference

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Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

30 June 2018

1 reference

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Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway

30 June 2018

1 reference

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Hedgehog: functions and mechanisms

30 June 2018

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Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice

30 June 2018

1 reference

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MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression

30 June 2018

1 reference

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The 2007 WHO classification of tumours of the central nervous system

30 June 2018

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Standard mutation nomenclature in molecular diagnostics: practical and educational challenges

30 June 2018

1 reference

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Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

30 June 2018

1 reference

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Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

30 June 2018

1 reference

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

30 June 2018

1 reference

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Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours

30 June 2018

1 reference

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Activation of the hedgehog pathway in advanced prostate cancer

30 June 2018

1 reference

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Suppressor of fused regulates Gli activity through a dual binding mechanism

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Characterization of the physical interaction of Gli proteins with SUFU proteins

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mutations in SUFU predispose to medulloblastoma

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Gli and hedgehog in cancer: tumours, embryos and stem cells.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Mutations affecting segment number and polarity in Drosophila

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Multiple Hereditary Infundibulocystic Basal Cell Carcinoma Syndrome Associated With a Germline SUFU Mutation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Multiple skin hamartomata: a possible novel clinical presentation of SUFU neoplasia syndrome.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Identification of a SUFU germline mutation in a family with Gorlin syndrome.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Loss of suppressor-of-fused function promotes tumorigenesis.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Retrospective family study of childhood medulloblastoma.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5920380

Loss of the chromosomal region 10q23-25 in prostate cancer

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29725392

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29725392

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3892/OL.2018.8142

1 reference

29 June 2018

PMC publication ID

5920380

1 reference

29 June 2018

PubMed publication ID

29725392

1 reference

29 June 2018