T cell activation results in conformational changes in the Src family kinase Lck to induce its activation. (Q54448667)

29 May 2018

title

T cell activation results in conformational changes in the Src family kinase Lck to induce its activation. (English)

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Hannes Stockinger

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author name string

Anja Stirnweiss

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Roland Hartig

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Steffi Gieseler

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Jonathan A Lindquist

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Peter Reichardt

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Lars Philipsen

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Luca Simeoni

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Mateusz Poltorak

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Camilla Merten

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Werner Zuschratter

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Yury Prokazov

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Thomas Harder

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Matthias Gunzer

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Burkhart Schraven

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publication date

19 February 2013

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29 May 2018

published in

Science Signaling

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volume

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issue

263

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page(s)

ra13

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Profound block in thymocyte development in mice lacking p56lck

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

21 January 2018

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Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

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Structure of the regulatory domains of the Src-family tyrosine kinase Lck

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Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines

21 January 2018

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Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases

21 January 2018

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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

21 January 2018

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

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Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

21 January 2018

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Lck Dephosphorylation at Tyr-394 and Inhibition of T Cell Antigen Receptor Signaling by Yersinia Phosphatase YopH

21 January 2018

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The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation

21 January 2018

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Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

21 January 2018

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T cell receptor triggering by force

21 January 2018

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Mechanisms for T cell receptor triggering

21 January 2018

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Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck.

21 January 2018

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Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cell

21 January 2018

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Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells

21 January 2018

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Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

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Time-resolved FRET fluorescence spectroscopy of visible fluorescent protein pairs.

21 January 2018

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High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion protein

21 January 2018

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Wide-Field Multi-Parameter FLIM: long-term minimal invasive observation of proteins in living cells

21 January 2018

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MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes.

21 January 2018

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Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.

21 January 2018

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Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

21 January 2018

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Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

21 January 2018

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003607

Global analysis of Förster resonance energy transfer in live cells measured by fluorescence lifetime imaging microscopy exploiting the rise time of acceptor fluorescence

21 January 2018

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Analyzing proteome topology and function by automated multidimensional fluorescence microscopy

21 January 2018

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10.1126/SCISIGNAL.2003607

21 January 2018

Identifiers

DOI

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29 May 2018

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29 May 2018