Constitutively active Lck kinase in T cells drives antigen receptor signal transduction (Q34376930)

1 August 2017

title

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction (English)

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1 August 2017

Mogjiborahman Salek

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Wolfgang Paster

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Thomas Höfer

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Vincenzo Cerundolo

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Omer Dushek

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1 August 2017

Lars Fugger

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ORCID Public Data File 2021

1 August 2017

Antonella Viola

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author name string

Konstantina Nika

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1 August 2017

Cristiana Soldani

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1 August 2017

Adrian Gray

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1 August 2017

Ruth Etzensperger

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1 August 2017

Paolo Polzella

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1 August 2017

Oreste Acuto

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1 August 2017

language of work or name

English

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publication date

11 June 2010

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

766-777

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The alphabeta T cell receptor is an anisotropic mechanosensor.

1 August 2017

cites work

1 reference

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Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck.

6 July 2018

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Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

6 July 2018

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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

6 July 2018

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Tailoring T-cell receptor signals by proximal negative feedback mechanisms

6 July 2018

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T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

6 July 2018

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Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

6 July 2018

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MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo

6 July 2018

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6 July 2018

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Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells

6 July 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

6 July 2018

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

6 July 2018

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

6 July 2018

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The interplay between Src family kinases and receptor tyrosine kinases

6 July 2018

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Structure and regulation of Src family kinases

6 July 2018

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Src family kinases, key regulators of signal transduction

6 July 2018

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Regulation of the Src family kinase Lck by Hsp90 and ubiquitination

6 July 2018

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Unc119, a novel activator of Lck/Fyn, is essential for T cell activation

6 July 2018

1 reference

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Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

6 July 2018

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Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts

6 July 2018

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Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells

6 July 2018

1 reference

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CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

6 July 2018

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CD45: a critical regulator of signaling thresholds in immune cells

6 July 2018

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

6 July 2018

1 reference

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

6 July 2018

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Detection of dimers of dimers of human leukocyte antigen (HLA)-DR on the surface of living cells by single-particle fluorescence imaging

6 July 2018

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

6 July 2018

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

6 July 2018

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Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

6 July 2018

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

6 July 2018

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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

6 July 2018

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The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

6 July 2018

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Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production

6 July 2018

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Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

6 July 2018

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Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

27 October 2018

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The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

27 October 2018

1 reference

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Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996607

Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.

27 October 2018

1 reference

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Regulation of Lck activity by CD4 and CD28 in the immunological synapse

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2996607

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

27 October 2018

1 reference

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alpha beta T cell receptor ligand-specific oligomerization revisited

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20541955

inferred from PubMed ID database lookup

12 December 2020

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Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20541955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.IMMUNI.2010.05.011

1 reference

1 August 2017

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1 August 2017

1 reference