Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. (Q54223958)

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English	Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.	scientific article

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25 March 2020

Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro (English)

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25 March 2020

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toll-like receptor

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1 reference

based on heuristic

inferred from title

inflammasome complex

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1

1 reference

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25 March 2020

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David J Dowling

2

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25 March 2020

Jianjin Xu

3

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25 March 2020

Lukasz S Ozog

4

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25 March 2020

Jaime A Mathew

5

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25 March 2020

Avinash Chander

6

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25 March 2020

Donglei Yin

7

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25 March 2020

Ofer Levy

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25 March 2020

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1 May 2018

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25 March 2020

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25 March 2020

13

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25 March 2020

5

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25 March 2020

e0196352

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25 March 2020

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Creative Commons Attribution 4.0 International

1 May 2018

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April 2022 Public Data File from Crossref

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0 references

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Update on Postnatal Steroids

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Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age.

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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.

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26 May 2018

Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns

1 reference

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26 May 2018

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.

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Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities

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Antiretroviral Therapy for HIV Infection: When to Initiate Therapy, Which Regimen to Use, and How to Monitor Patients on Therapy.

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26 May 2018

Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial

1 reference

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26 May 2018

Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation

1 reference

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26 May 2018

Pentoxifylline therapy for late-onset sepsis in preterm infants: a randomized controlled trial

1 reference

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26 May 2018

Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways

1 reference

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26 May 2018

Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5929513

26 May 2018

Pentoxifylline for the prevention of bronchopulmonary dysplasia in preterm infants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5929513

26 May 2018

Pharmacokinetics, microbial response, and pulmonary outcomes of multidose intravenous azithromycin in preterm infants at risk for Ureaplasma respiratory colonization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5929513

26 May 2018

Soluble mediators regulating immunity in early life

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26 May 2018

Post-infectious immune suppression: a new paradigm of severe infections.

1 reference

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26 May 2018

Management of neonatal sepsis in term newborns

1 reference

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26 May 2018

Is boosting the immune system in sepsis appropriate?

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26 May 2018

Ontogeny of early life immunity

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26 May 2018

Infection-induced inflammation and cerebral injury in preterm infants

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26 May 2018

Systemic inflammation and cerebral palsy risk in extremely preterm infants

1 reference

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26 May 2018

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

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26 May 2018

Plasma-mediated immune suppression: a neonatal perspective

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26 May 2018

Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly

1 reference

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26 May 2018

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

1 reference

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26 May 2018

Differential Effects of Low- and High-dose Glucocorticoids on the Innate Immunity of Corneal Epithelium in Vitro

1 reference

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26 May 2018

Azithromycin distinctively modulates classical activation of human monocytes in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5929513

26 May 2018

Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

1 reference

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26 May 2018

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells

1 reference

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26 May 2018

Pentoxifylline in preterm neonates: a systematic review

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26 May 2018

Adjunctive immunologic interventions in neonatal sepsis

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26 May 2018

TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia

1 reference

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26 May 2018

The role of Toll-like receptors in perinatal brain injury

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26 May 2018

Cyclic AMP: master regulator of innate immune cell function.

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26 May 2018

Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities

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26 May 2018

Innate immunity of the newborn: basic mechanisms and clinical correlates

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26 May 2018

Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo

1 reference

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26 May 2018

The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

1 reference

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1 reference

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Sequelae of chorioamnionitis

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Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes.

1 reference

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26 May 2018

What is synergy?

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Childhood leukemia as a model for cancer research: the Richard and Hinda Rosenthal Foundation Award Lecture

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Late (> 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

1 reference

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Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.

1 reference

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Simultaneous determination of pentoxifylline, metabolites M1 (lisofylline), M4 and M5, and caffeine in plasma and dried blood spots for pharmacokinetic studies in preterm infants and neonates.

1 reference

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1 reference

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13 August 2018

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of dexamethasone in premature neonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentoxifylline exerts synergistic immunomodulatory effects in combination with dexamethasone or cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human interleukin-12 production by pentoxifylline

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal adaptive immunity comes of age

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of pentoxifylline on lung inflammation in a rat model of meconium aspiration syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulatory effects of azithromycin on the establishment of lipopolysaccharide tolerance in mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29715306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0196352

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29715306%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29715306%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29715306%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

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