Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants (Q28741059)

Hilton Whittle

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Assan Jaye

Assan Jaye

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Katie L Flanagan

Katie L Flanagan

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Ebrima Touray

Ebrima Touray

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Momodou Cox

Momodou Cox

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author name string

John Townend

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Uche J Adetifa

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Victoria J Philbin

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Christy Mancuso

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Beate Kampmann

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Ofer Levy

Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

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language of work or name

English

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publication date

13 April 2011

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e18185

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cites work

1 reference

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Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

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Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial

17 March 2017

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

17 March 2017

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

17 March 2017

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Hay fever, hygiene, and household size

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Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

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3 June 2018

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Vaccine Adjuvants: Putting Innate Immunity to Work

3 June 2018

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Immunomodulators as adjuvants for vaccines and antimicrobial therapy

3 June 2018

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IL-6: regulator of Treg/Th17 balance

3 June 2018

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Acquisition of adult-like TLR4 and TLR9 responses during the first year of life

3 June 2018

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Developmental biology of the innate immune response: implications for neonatal and infant vaccine development

3 June 2018

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Neonatal innate TLR-mediated responses are distinct from those of adults.

3 June 2018

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Precarious balance: Th17 cells in host defense.

3 June 2018

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AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

3 June 2018

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Neonatal innate immunity in allergy development

3 June 2018

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Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.

3 June 2018

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Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy

3 June 2018

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Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea

3 June 2018

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Phenotype and function of neonatal DC.

3 June 2018

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Immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in healthy boys aged 10-18 years

3 June 2018

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Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

3 June 2018

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From tolerance to autoimmunity: is there a risk in early life vaccination?

3 June 2018

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Mycobacteria and allergies.

3 June 2018

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Innate immunity of the newborn: basic mechanisms and clinical correlates

3 June 2018

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Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo

3 June 2018

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The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

3 June 2018

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

3 June 2018

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Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

3 June 2018

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Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory

3 June 2018

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Innate cellular immune responses in newborns

3 June 2018

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Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.

3 June 2018

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Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses

3 June 2018

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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

3 June 2018

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Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide.

3 June 2018

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Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity

3 June 2018

1 reference

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Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

3 June 2018

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Further checkpoints in Th1 development

3 June 2018

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Neonatal and early life vaccinology

3 June 2018

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Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors

3 June 2018

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

3 June 2018

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Regulation of interleukin-12 signal transduction during T helper phenotype development

3 June 2018

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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

3 June 2018

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Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses.

3 June 2018

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Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion.

21 January 2018

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Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood

21 January 2018

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Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants

21 January 2018

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Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations.

21 January 2018

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Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.

21 January 2018

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BCG stimulated dendritic cells induce an interleukin-10 producing T-cell population with no T helper 1 or T helper 2 bias in vitro

21 January 2018

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Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response

21 January 2018

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Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes.

21 January 2018

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Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology

21 January 2018

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Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination

27 November 2018

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Postnatal Development of Monocyte Cytokine Responses to Bacterial Lipopolysaccharide

27 November 2018

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The interferon-alpha and interleukin-10 responses in neonates differ from adults, and their production remains partial throughout the first 18 months of life

21 January 2018

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12 December 2020

Challenges in infant immunity: implications for responses to infection and vaccines

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12 December 2020

Safety and immunogenicity profile of an experimental hepatitis B vaccine adjuvanted with AS04

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12 December 2020

Adjuvant activities of immune response modifier R-848: comparison with CpG ODN

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12 December 2020

10.1371/JOURNAL.PONE.0018185

Identifiers

DOI

1 reference

ADS bibcode

2011PLoSO...618185B

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1 reference

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PubMed publication ID

21533209

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