Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay (Q43655919)

25 November 2017

title

Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay (English)

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25 November 2017

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25 November 2017

Maurici D

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25 November 2017

Monti P

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25 November 2017

North S

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25 November 2017

Frebourg T

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25 November 2017

Fronza G

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25 November 2017

Hainaut P

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25 November 2017

language of work or name

English

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publication date

1 June 2001

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25 November 2017

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25 November 2017

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25 November 2017

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25 November 2017

page(s)

3533-3540

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Inactivation of the p53 protein in cell lines derived from human esophageal cancers

25 November 2017

cites work

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay

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WAF1, a potential mediator of p53 tumor suppression

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A simple p53 functional assay for screening cell lines, blood, and tumors

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Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer

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Screening thep53 status of human cell lines using a yeast functional assay

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Identification of p53 as a sequence-specific DNA-binding protein

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Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.

21 January 2018

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Stable reintroduction of wild-type P53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells

21 January 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

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Functional interaction between GCN5 and polyamines: a new role for core histone acetylation

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Role of cysteine residues in regulation of p53 function

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Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

21 January 2018

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

21 January 2018

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

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Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721

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7 January 2021

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

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7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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7 January 2021

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

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7 January 2021

Screening patients for heterozygous p53 mutations using a functional assay in yeast

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7 January 2021

Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent

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7 January 2021

p53 status and the efficacy of cancer therapy in vivo

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7 January 2021

In vitro antioxidant properties of amifostine (WR-2721, Ethyol)

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7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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7 January 2021

Photoguides offer nurses an easy, cost-effective review

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7 January 2021

High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis

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7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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7 January 2021

Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278)

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204428

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Dimensions Publication ID

25 November 2017

1023747035

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