VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. (Q43455466)

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scientific article published on 24 February 2008

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English	VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.	scientific article published on 24 February 2008

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PubMed publication ID

18297059

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23 November 2017

title

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. (English)

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PubMed publication ID

18297059

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23 November 2017

author

Susanne Schlisio

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2

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18297059

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23 November 2017

Yoji Andrew Minamishima

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3

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18297059

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23 November 2017

Qing Zhang

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Qing Zhang

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4

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William G. Kaelin

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8

object named as

William G Kaelin

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18297059

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23 November 2017

Sabina Signoretti

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7

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Sabina Signoretti

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18297059

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23 November 2017

author name string

Arthur P Young

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1

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23 November 2017

Lianjie Li

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Chiara Grisanzio

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6

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23 November 2017

publication date

24 February 2008

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18297059

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23 November 2017

published in

Nature Cell Biology

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23 November 2017

volume

10

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issue

3

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23 November 2017

page(s)

361-369

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Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

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Cellular senescence: mitotic clock or culture shock?

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Tissue-specific inactivation of p53 tumor suppression in the mouse

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Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

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Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

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The p400 complex is an essential E1A transformation target

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p400 is required for E1A to promote apoptosis

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The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

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HIF1alpha delays premature senescence through the activation of MIF.

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HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

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Telomerase maintains telomere structure in normal human cells.

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Hypoxia inhibits G1/S transition through regulation of p27 expression

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Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

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Kip1 meets SKP2: new links in cell-cycle control

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Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

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7 January 2021

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Identifiers

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10.1038/NCB1699

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18297059

retrieved

23 November 2017

PubMed publication ID

18297059

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18297059

retrieved

23 November 2017

 

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