IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes (Q43422361)

23 November 2017

title

IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes (English)

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23 November 2017

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Magdalena Koziczak-Holbro

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23 November 2017

Anton Glück

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23 November 2017

Claude Tschopp

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23 November 2017

John C Mathison

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23 November 2017

Hermann Gram

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23 November 2017

language of work or name

English

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publication date

1 March 2008

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European Journal of Immunology

23 November 2017

published in

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23 November 2017

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23 November 2017

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23 November 2017

page(s)

788-796

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

23 November 2017

cites work

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Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations

21 January 2018

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Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation

21 January 2018

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Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade

21 January 2018

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PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages

21 January 2018

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IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide- Induced Activation of APC

21 January 2018

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21 January 2018

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7 January 2021

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

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7 January 2021

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

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7 January 2021

Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling

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7 January 2021

Modulation of Toll-interleukin 1 receptor mediated signaling

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7 January 2021

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

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7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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7 January 2021

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

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7 January 2021

NF-kappaB: a key role in inflammatory diseases

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7 January 2021

AP-1: one switch for many signals

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7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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7 January 2021

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

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7 January 2021

IRAK-4 as the central TIR signaling mediator in innate immunity

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7 January 2021

IRAK-4: a new drug target in inflammation, sepsis, and autoimmunity

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7 January 2021

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

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7 January 2021

Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

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7 January 2021

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

1 reference

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7 January 2021

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

1 reference

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7 January 2021

IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and interferon-gamma reveals MCP-3 heterogeneity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

TLR signaling pathways

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

AU-rich elements: characterization and importance in mRNA degradation

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7 January 2021

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes

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7 January 2021

Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

TNF-alpha induced CD38 expression in human airway smooth muscle cells: role of MAP kinases and transcription factors NF-kappaB and AP-1

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Pyogenic bacterial infections in humans with IRAK-4 deficiency

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Type I interferons (alpha/beta) in immunity and autoimmunity

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

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https://api.crossref.org/works/10.1002%2FEJI.200737886

7 January 2021

Identifiers

DOI

10.1002/EJI.200737886

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23 November 2017

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