Molecular details of Bax activation, oligomerization, and membrane insertion. (Q42910802)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008353%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Molecular details of Bax activation, oligomerization, and membrane insertion (English)

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15 January 2020

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15 January 2020

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15 January 2020

Heinz-Jürgen Steinhoff

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15 January 2020

Mirjam Classen

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15 January 2020

Pulagam V L Padmavathi

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15 January 2020

Kornelius Zeth

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15 January 2020

Enrica Bordignon

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15 January 2020

language of work or name

English

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publication date

12 December 2009

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

285

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15 January 2020

issue

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15 January 2020

page(s)

6636-6647

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Detergent-activated BAX protein is a monomer

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Conformational changes and protein stability of the pro-apoptotic protein Bax.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

BAX activation is initiated at a novel interaction site

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

The directed cooperative assembly of proteorhodopsin into 2D and 3D polarized arrays

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

A structure-based simulation approach for electron paramagnetic resonance spectra using molecular and stochastic dynamics simulations.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Solution NMR of membrane proteins: practice and challenges

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Mitochondrial fission in apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Accessibility of nitroxide side chains: absolute Heisenberg exchange rates from power saturation EPR

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Coot: model-building tools for molecular graphics

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Conformation of membrane-associated proapoptotic tBid

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bcl-2-family proteins and the role of mitochondria in apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

The Bcl2 family: regulators of the cellular life-or-death switch

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Structure of Bax: coregulation of dimer formation and intracellular localization

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Conformation of the Bax C-terminus regulates subcellular location and cell death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Solution structure of BID, an intracellular amplifier of apoptotic signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

A collision gradient method to determine the immersion depth of nitroxides in lipid bilayers: application to spin-labeled mutants of bacteriorhodopsin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

A simple method for displaying the hydropathic character of a protein

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

BCL-XL dimerization by three-dimensional domain swapping.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825459

DeerAnalysis2006—a comprehensive software package for analyzing pulsed ELDOR data

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.081539

Dead-Time Free Measurement of Dipole–Dipole Interactions between Electron Spins

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.081539

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

21 January 2018

1 reference

12 December 2020

Calpain-1 Regulates Bax and Subsequent Smac-dependent Caspase-3 Activation in Neutrophil Apoptosis

1 reference

12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

12 December 2020

Impact of pH on Bax alpha conformation, oligomerisation and mitochondrial integration

1 reference

12 December 2020

Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.081539

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008353%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008353%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

20008353

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20008353%20AND%20SRC:MED&resulttype=core&format=json