BAX activation is initiated at a novel interaction site (Q27652635)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

BAX activation is initiated at a novel interaction site (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author

Evripidis Gavathiotis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Loren D Walensky

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Marguerite L Davis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Gregory H Bird

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Samuel G Katz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Ho-Chou Tu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Hyungjin Kim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Emily H-Y Cheng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Nico Tjandra

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

1 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

455

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

7216

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

1076-1081

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

25 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

A stapled BID BH3 helix directly binds and activates BAX

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Structure of Bax: coregulation of dimer formation and intracellular localization

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Conformation of the Bax C-terminus regulates subcellular location and cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Movement of Bax from the cytosol to mitochondria during apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

BID: a novel BH3 domain-only death agonist

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Cell death: critical control points

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

The BCL-2 protein family: opposing activities that mediate cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

BCL-2 in the crosshairs: tipping the balance of life and death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Bcl-2 changes conformation to inhibit Bax oligomerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Conformational control of Bax localization and apoptotic activity by Pro168.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Structural biology of the Bcl-2 family of proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

BH3-Only proteins-essential initiators of apoptotic cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Regulated targeting of BAX to mitochondria.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Involvement of the N-terminus of Bax in its intracellular localization and function.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597110

Nonionic detergents induce dimerization among members of the Bcl-2 family

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18948948

12 December 2020

inferred from PubMed ID database lookup

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18948948

12 December 2020

inferred from PubMed ID database lookup

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18948948

12 December 2020

inferred from PubMed ID database lookup

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE07396

7 January 2021

inferred from DOI database lookup

The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE07396

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE07396

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 December 2019

1036508338

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

18948948

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948948%20AND%20SRC:MED&resulttype=core&format=json