Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria (Q42848863)

8 November 2017

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria (English)

1 reference

8 November 2017

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8 November 2017

Hannah R Bridges

1 reference

8 November 2017

Andrew J Y Jones

series ordinal

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8 November 2017

Michael N Pollak

series ordinal

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8 November 2017

language of work or name

English

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publication date

1 September 2014

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8 November 2017

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8 November 2017

462

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8 November 2017

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8 November 2017

475-487

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Creative Commons Attribution 3.0 Unported

8 November 2017

start time

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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Metformin--mode of action and clinical implications for diabetes and cancer

27 May 2018

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Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

27 May 2018

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A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase

27 May 2018

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Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II.

27 May 2018

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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

27 May 2018

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

27 May 2018

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27 May 2018

Mitochondrial complex I.

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Crystal structure of the entire respiratory complex I

27 May 2018

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

27 May 2018

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Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria

27 May 2018

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Metformin and the risk of cancer: time-related biases in observational studies

27 May 2018

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Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

27 May 2018

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Investigating metformin for cancer prevention and treatment: the end of the beginning

27 May 2018

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The deactive form of respiratory complex I from mammalian mitochondria is a Na+/H+ antiporter

27 May 2018

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Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

27 May 2018

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Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

27 May 2018

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Metformin reduces endogenous reactive oxygen species and associated DNA damage

27 May 2018

1 reference

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Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

27 May 2018

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Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels

27 May 2018

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Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

27 May 2018

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Role of solvation effects in protein denaturation: from thermodynamics to single molecules and back

27 May 2018

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Metformin activates AMP kinase through inhibition of AMP deaminase

27 May 2018

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

27 May 2018

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Pharmacogenetics of antimalarial drugs: effect on metabolism and transport

27 May 2018

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Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

27 May 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

27 May 2018

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ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding

27 May 2018

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How mitochondria produce reactive oxygen species

27 May 2018

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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

27 May 2018

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Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I.

27 May 2018

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How the regulatory protein, IF1, inhibits F1-ATPase from bovine mitochondria

27 May 2018

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Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

27 May 2018

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Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.

27 May 2018

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Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.

27 May 2018

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A Note on the Kinetics of Enzyme Action

27 May 2018

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Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria

27 May 2018

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The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer

27 May 2018

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Partial resolution of the enzymes catalyzing oxidative phosphorylation. I. Purification and properties of soluble dinitrophenol-stimulated adenosine triphosphatase.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

The nuclear encoded subunits of complex I from bovine heart mitochondria

27 May 2018

1 reference

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A role for native lipids in the stabilization and two-dimensional crystallization of the Escherichia coli NADH-ubiquinone oxidoreductase (complex I).

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

The multiple dose pharmacokinetics of proguanil

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

F1F0-ATP synthase from bovine heart mitochondria: development of the purification of a monodisperse oligomycin-sensitive ATPase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Inhibitors and activators of the mitochondrial reduced diphosphopyridine nucleotide dehydrogenase.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Reactions of the flavin mononucleotide in complex I: a combined mechanism describes NADH oxidation coupled to the reduction of APAD+, ferricyanide, or molecular oxygen

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

The respiratory complexes I from the mitochondria of two Pichia species

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Reduction of the iron-sulfur clusters in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by EuII-DTPA, a very low potential reductant

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Metformin promotes isolated rat liver mitochondria impairment.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148174

16 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25017630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thermodynamic analysis of flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25017630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25017630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BJ20140620

1 reference

8 November 2017

1 reference

8 November 2017

PubMed publication ID

25017630

1 reference