Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts (Q42827824)

8 November 2017

title

Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts (English)

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8 November 2017

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8 November 2017

Guan JL

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8 November 2017

language of work or name

English

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publication date

1 June 2001

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8 November 2017

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8 November 2017

volume

499

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8 November 2017

issue

1-2

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8 November 2017

page(s)

176-181

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Integrins: emerging paradigms of signal transduction

8 November 2017

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Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

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Focal adhesion kinase promotes phospholipase C-gamma1 activity.

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle

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Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration

7 January 2021

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10.1016/S0014-5793(01)02545-5

7 January 2021

Identifiers

DOI

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8 November 2017

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