Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. (Q42702121)

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24 January 2020

title

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression (English)

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24 January 2020

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24 January 2020

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24 January 2020

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24 January 2020

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24 January 2020

Michael R Botchan

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24 January 2020

Ilze Matise

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24 January 2020

Tavanna Buske

series ordinal

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24 January 2020

Naoko Shima

series ordinal

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24 January 2020

publication date

1 March 2011

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24 January 2020

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24 January 2020

volume

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24 January 2020

issue

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24 January 2020

page(s)

543-553

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The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

24 January 2020

cites work

1 reference

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Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

27 May 2018

1 reference

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DNA damage response and tumorigenesis in Mcm2-deficient mice

27 May 2018

1 reference

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Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle

27 May 2018

1 reference

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

27 May 2018

1 reference

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Genomic instability--an evolving hallmark of cancer

27 May 2018

1 reference

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Aneuploidy and improved growth are coincident but not causal in a yeast cancer model

27 May 2018

1 reference

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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

27 May 2018

1 reference

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The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

27 May 2018

1 reference

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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

27 May 2018

1 reference

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

27 May 2018

1 reference

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An oncogene-induced DNA damage model for cancer development

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

27 May 2018

1 reference

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Cell cycle regulation of DNA replication.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

The ATR pathway: fine-tuning the fork

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Preventing re-replication of chromosomal DNA.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

In search of the holy replicator

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Eukaryotic MCM proteins: beyond replication initiation

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

ATR Regulates Fragile Site Stability

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

The Pezcoller lecture: cancer cell cycles revisited

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

MCM proteins in DNA replication

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Cytokinesis-block micronucleus cytome assay.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3062258

Non-denaturing fluorescence in situ hybridization to find replication origins in a specific genome region on the DNA fiber

16 August 2018

1 reference

12 December 2020

Role for BLM in replication-fork restart and suppression of origin firing after replicative stress

1 reference

12 December 2020

On the origins of ultra-fine anaphase bridges

1 reference

12 December 2020

Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix

1 reference

12 December 2020

10.1016/J.MOLCEL.2011.02.006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21362550%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21362550%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21362550

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21362550%20AND%20SRC:MED&resulttype=core&format=json