The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities (Q34982804)

5 August 2017

title

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities (English)

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5 August 2017

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Valeria Naim

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5 August 2017

Filippo Rosselli

series ordinal

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5 August 2017

language of work or name

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24 May 2009

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5 August 2017

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

761-768

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The Fanconi anaemia/BRCA pathway

5 August 2017

cites work

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Cancer-susceptibility genes. Gatekeepers and caretakers

21 January 2018

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The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

21 January 2018

1 reference

A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

21 January 2018

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BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks

21 January 2018

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

21 January 2018

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

21 January 2018

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

21 January 2018

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Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia.

21 January 2018

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Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

21 January 2018

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Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

21 January 2018

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Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2

21 January 2018

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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

21 January 2018

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BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

21 January 2018

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Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype

21 January 2018

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Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

21 January 2018

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Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

21 January 2018

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Phosphorylation of histone H2AX at M phase in human cells without DNA damage response

21 January 2018

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Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation

21 January 2018

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The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

21 January 2018

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Cytokinesis-block micronucleus cytome assay.

21 January 2018

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PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

21 January 2018

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Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes

21 January 2018

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Fragile sites and chromosome instability: the distribution of breaks induced by cis-diamine-clichloro-platinum (II) in Fanconi anemia lymphocyte cultures

21 January 2018

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Spontaneous chromosome aberrations in Fanconi's anemia patients are located at fragile sites and acute myeloid leukemia breakpoints

21 January 2018

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12 December 2020

FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination.

1 reference

12 December 2020

Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

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12 December 2020

Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis

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12 December 2020

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

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12 December 2020

Ultrastructure of Fanconi anemia fibroblasts

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12 December 2020

Identifiers

DOI

10.1038/NCB1883

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Dimensions Publication ID

5 August 2017

1034751837

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