Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct (Q42709265)

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scientific article published on 23 September 2013

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English	Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct	scientific article published on 23 September 2013

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PubMed publication ID

24061166

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5 November 2017

title

Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct (English)

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PubMed publication ID

24061166

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5 November 2017

author

Kateřina Vávrová

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1

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14 June 2020

Michaela Sochorová

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Barbora Školová

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Stephan Schreml

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Dominika Henkes

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2

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Kay Strüver

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3

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14 June 2020

Madeleine Y Witting

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6

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14 June 2020

Wolfgang Friess

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7

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14 June 2020

Robert J Meier

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9

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14 June 2020

Joachim W Fluhr

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11

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14 June 2020

Sarah Küchler

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12

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14 June 2020

Monika Schäfer-Korting

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10

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24061166

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14 June 2020

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English

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publication date

23 September 2013

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24061166

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5 November 2017

published in

Journal of Investigative Dermatology

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24061166

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14 June 2020

volume

134

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14 June 2020

issue

3

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24061166

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14 June 2020

page(s)

746-753

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14 June 2020

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Abnormalities in Epidermal Lipid Metabolism in Patients with Atopic Dermatitis

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PubMed

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12 December 2020

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Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights

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12 December 2020

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Lipids and barrier function of the skin

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PubMed

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12 December 2020

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Unraveling barrier properties of three different in-house human skin equivalents

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Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity

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12 December 2020

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Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

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12 December 2020

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Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid

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12 December 2020

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Filaggrin in atopic dermatitis

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Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin

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12 December 2020

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Changes in the ceramide profile of atopic dermatitis patients

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12 December 2020

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Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis

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12 December 2020

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A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

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12 December 2020

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Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

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12 December 2020

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Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema

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12 December 2020

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Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down.

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12 December 2020

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PREPARATION OF ISOLATED SHEETS OF HUMAN STRATUM CORNEUM

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12 December 2020

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The use of reconstructed human epidermis for skin absorption testing: Results of the validation study

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12 December 2020

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Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

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12 December 2020

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Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum

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12 December 2020

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High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis

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12 December 2020

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NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging

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12 December 2020

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Short-chain ceramides decrease skin barrier properties.

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12 December 2020

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Lipid biophysics of water loss through the skin

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12 December 2020

based on heuristic

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Decrease of Ceramides with Very Long–Chain Fatty Acids and Downregulation of Elongases in a Murine Atopic Dermatitis Model

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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Variability of enzyme markers during clinical regression of atopic dermatitis

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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Simultaneous photographing of oxygen and pH in vivo using sensor films

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12 December 2020

based on heuristic

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Influence of the lipid composition on the organization of skin lipid model mixtures: an infrared spectroscopy investigation

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12 December 2020

based on heuristic

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Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model

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based on heuristic

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Noninvasive characterization of human stratum corneum of undiseased skin of patients with atopic dermatitis and psoriasis as studied by Fourier transform Raman spectroscopy

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12 December 2020

based on heuristic

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Acidification in the epidermis and the role of secretory phospholipases

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

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Infrared determination of conformational order and phase behavior in ceramides and stratum corneum models

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/24061166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2D luminescence imaging of pH in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skin constructs for replacement of skin tissues for in vitro testing

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One remarkable molecule: filaggrin.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/24061166

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/JID.2013.402

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stated in

Europe PubMed Central

PubMed publication ID

24061166

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24061166%20AND%20SRC:MED&resulttype=core&format=json

retrieved

14 June 2020

Dimensions Publication ID

1035166555

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PubMed publication ID

24061166

1 reference

stated in

Europe PubMed Central

PubMed publication ID

24061166

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24061166%20AND%20SRC:MED&resulttype=core&format=json

retrieved

14 June 2020

ResearchGate publication ID

256983704

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