Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model (Q43072814)

13 November 2017

title

Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model (English)

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13 November 2017

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13 November 2017

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13 November 2017

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13 November 2017

Florian Gruber

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Jiang Jin

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13 November 2017

Sanja Kezic

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13 November 2017

Caterina Barresi

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13 November 2017

Caroline Stremnitzer

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13 November 2017

Maria Buchberger

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13 November 2017

Veronika Mlitz

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13 November 2017

Claudia Ballaun

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13 November 2017

Barbara Sterniczky

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13 November 2017

Dagmar Födinger

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13 November 2017

language of work or name

English

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publication date

6 May 2010

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Journal of Investigative Dermatology

13 November 2017

published in

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13 November 2017

volume

130

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13 November 2017

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13 November 2017

page(s)

2286-2294

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The cornified envelope: a model of cell death in the skin

13 November 2017

cites work

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7 January 2021

Assembly of stratum corneum basic protein and keratin filaments in macrofibrils

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7 January 2021

Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with alteration of cell shape and nuclear integrity

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https://api.crossref.org/works/10.1038%2FJID.2010.115

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Caspase-14 protects against epidermal UVB photodamage and water loss

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Caspase-14 reveals its secrets

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7 January 2021

Differential extraction of keratin subunits and filaments from normal human epidermis

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7 January 2021

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.

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7 January 2021

Organization, structure, and polymorphisms of the human profilaggrin gene

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Histidine-rich proteins (filaggrins): Structural and functional heterogeneity during epidermal differentiation

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7 January 2021

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study

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7 January 2021

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland

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7 January 2021

Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods

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7 January 2021

The extraction and characterization of human nail keratin

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7 January 2021

Cellular features of differentiation in the nail

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

The filaggrin story: novel insights into skin-barrier function and disease

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Identification of a major keratinocyte cell envelope protein, loricrin

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Gene silencing in a human organotypic skin model

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Diseases associated with photosensitivity

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution

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7 January 2021

A new mathematical model for relative quantification in real-time RT-PCR

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7 January 2021

Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Epithelial structural proteins of the skin and oral cavity: function in health and disease

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Evidence for specific proteolytic cleavage of the N-terminal domain of human profilaggrin during epidermal differentiation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell-cell adhesion, and cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Filaggrin in the frontline: role in skin barrier function and disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Histidine-rich protein of the keratohyalin granules. Source of the free amino acids, urocanic acid and pyrrolidone carboxylic acid in the stratum corneum.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Klf4 is a transcription factor required for establishing the barrier function of the skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Characterization of a class of cationic proteins that specifically interact with intermediate filaments

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

A variety of skin responses to ultraviolet irradiation in patients with atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Throwing a light on photosensitivity in atopic dermatitis: a retrospective study

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Involucrin and Other Markers of Keratinocyte Terminal Differentiation

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Is filaggrin really a filament-aggregating protein in vivo?

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Sun-screening effect of urocanic acid

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https://api.crossref.org/works/10.1038%2FJID.2010.115

7 January 2021

Identifiers

DOI

10.1038/JID.2010.115

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Dimensions Publication ID

13 November 2017

1032873742

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