Conformational states of the kinase Lck regulate clustering in early T cell signaling (Q42679142)

4 November 2017

title

Conformational states of the kinase Lck regulate clustering in early T cell signaling (English)

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4 November 2017

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4 November 2017

Katharina Gaus

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4 November 2017

Jérémie Rossy

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4 November 2017

Dylan M Owen

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4 November 2017

Zhengmin Yang

series ordinal

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4 November 2017

language of work or name

English

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publication date

2 December 2012

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4 November 2017

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4 November 2017

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4 November 2017

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4 November 2017

page(s)

82-89

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Src family kinases, key regulators of signal transduction

4 November 2017

cites work

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T-cell-antigen recognition and the immunological synapse

21 January 2018

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Mechanisms for T cell receptor triggering

21 January 2018

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

21 January 2018

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

21 January 2018

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Structure and regulation of Src family kinases

21 January 2018

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CD45: a critical regulator of signaling thresholds in immune cells

21 January 2018

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Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45.

21 January 2018

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CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cells.

21 January 2018

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Lck and the nature of the T cell receptor trigger

21 January 2018

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21 January 2018

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Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck.

21 January 2018

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Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

21 January 2018

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The kinetic-segregation model: TCR triggering and beyond

21 January 2018

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

21 January 2018

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Merging complexes: properties of membrane raft assembly during lymphocyte signaling

21 January 2018

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

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Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

21 January 2018

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Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

21 January 2018

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Imaging intracellular fluorescent proteins at nanometer resolution

21 January 2018

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Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)

21 January 2018

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Direct stochastic optical reconstruction microscopy with standard fluorescent probes

21 January 2018

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PALM imaging and cluster analysis of protein heterogeneity at the cell surface

21 January 2018

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

21 January 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

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Condensation of the plasma membrane at the site of T lymphocyte activation

21 January 2018

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Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

21 January 2018

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Functional implications of plasma membrane condensation for T cell activation

21 January 2018

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The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity

21 January 2018

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Negative regulation of Lck by Cbl ubiquitin ligase

21 January 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

21 January 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 January 2018

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The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

21 January 2018

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Binding specificity of SH2 domains: insight from free energy simulations

21 January 2018

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T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering

21 January 2018

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High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

21 January 2018

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

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Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation

21 January 2018

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Membrane phosphatidylserine regulates surface charge and protein localization

21 January 2018

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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

21 January 2018

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Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

21 January 2018

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The safety on the TCR trigger

21 January 2018

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A negatively charged domain of LAT mediates its interaction with the active form of Lck.

21 January 2018

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Quantitative photo activated localization microscopy: unraveling the effects of photoblinking

21 January 2018

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How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

21 January 2018

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12 December 2020

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

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12 December 2020

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes

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12 December 2020

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

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12 December 2020

Identifiers

DOI

10.1038/NI.2488

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4 November 2017

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