High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? (Q42491304)

1 November 2017

title

High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? (English)

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1 November 2017

T Crook

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1 November 2017

J M Nicholls

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1 November 2017

L Brooks

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1 November 2017

J O'Nions

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1 November 2017

M J Allday

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1 November 2017

language of work or name

English

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publication date

1 July 2000

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1 November 2017

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1 November 2017

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1 November 2017

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1 November 2017

page(s)

3439-3444

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Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

1 November 2017

cites work

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Mdm2 promotes the rapid degradation of p53

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21 January 2018

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Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

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Regulation of p53 stability by Mdm2

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p53, the cellular gatekeeper for growth and division

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p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status

21 January 2018

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p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

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Association of Epstein-Barr virus infection with p53 protein accumulation but not bcl-2 protein in nasopharyngeal carcinoma

21 January 2018

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P53 overexpression and Epstein-Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas

21 January 2018

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Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma.

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 January 2018

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Assessment of p53 expression in nasopharyngeal carcinoma

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma

21 January 2018

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

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Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer

21 January 2018

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7 January 2021

The CDKN2A (p16) gene and human cancer.

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7 January 2021

Mechanisms of p16INK4A inactivation in non small-cell lung cancers

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7 January 2021

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes

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7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

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7 January 2021

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203656

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Dimensions Publication ID

1 November 2017

1047460616

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1 reference