Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. (Q42151791)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28082357%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis (English)

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9 April 2020

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9 April 2020

1 reference

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Markus Tschurtschenthaler

9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

1 reference

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9 April 2020

C Janneke van der Woude

1 reference

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9 April 2020

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9 April 2020

1 reference

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9 April 2020

Maikel P Peppelenbosch

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9 April 2020

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9 April 2020

Stephan R Targan

1 reference

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9 April 2020

Timon E Adolph

1 reference

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9 April 2020

Lukas Niederreiter

1 reference

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9 April 2020

Gwenny M Fuhler

1 reference

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9 April 2020

Miles Parkes

1 reference

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9 April 2020

Richard S Blumberg

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9 April 2020

language of work or name

English

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publication date

12 January 2017

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Journal of Experimental Medicine

9 April 2020

published in

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9 April 2020

volume

214

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9 April 2020

issue

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9 April 2020

page(s)

401-422

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NOD1 and NOD2 signalling links ER stress with inflammation.

9 April 2020

cites work

1 reference

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29 May 2018

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IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

29 May 2018

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29 May 2018

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

29 May 2018

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Role of Autophagy in the Maintenance of Intestinal Homeostasis

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Regulation of endoplasmic reticulum turnover by selective autophagy

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Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence.

29 May 2018

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Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes

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Geographical patterns of the standing and active human gut microbiome in health and IBD.

29 May 2018

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Measures of obesity and risk of Crohn's disease and ulcerative colitis

29 May 2018

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Recombinant Clostridium difficile toxin B induces endoplasmic reticulum stress in mouse colonal carcinoma cells

29 May 2018

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Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway

29 May 2018

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29 May 2018

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Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

29 May 2018

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29 May 2018

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Getting RIDD of RNA: IRE1 in cell fate regulation

29 May 2018

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The treatment-naive microbiome in new-onset Crohn's disease

29 May 2018

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A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

29 May 2018

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MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice

29 May 2018

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29 May 2018

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Paneth cells as a site of origin for intestinal inflammation.

29 May 2018

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Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

29 May 2018

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ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

29 May 2018

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Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

29 May 2018

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Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection

29 May 2018

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Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

29 May 2018

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IRE1: ER stress sensor and cell fate executor

29 May 2018

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Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform.

29 May 2018

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29 May 2018

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RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

29 May 2018

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

29 May 2018

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29 May 2018

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Paneth cells: maestros of the small intestinal crypts

29 May 2018

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Negative feedback by IRE1β optimizes mucin production in goblet cells

29 May 2018

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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

29 May 2018

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The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

29 May 2018

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The ER stress transducer IRE1β is required for airway epithelial mucin production

29 May 2018

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

29 May 2018

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The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

29 May 2018

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Structural basis of the unfolded protein response

29 May 2018

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Activation of the unfolded protein response by Listeria monocytogenes

29 May 2018

1 reference

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The unfolded protein response: from stress pathway to homeostatic regulation

29 May 2018

1 reference

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The unfolded protein response: integrating stress signals through the stress sensor IRE1α

29 May 2018

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Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

29 May 2018

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UCHIME improves sensitivity and speed of chimera detection

29 May 2018

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Intestinal homeostasis and its breakdown in inflammatory bowel disease

29 May 2018

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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

29 May 2018

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

29 May 2018

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Biogenesis and cargo selectivity of autophagosomes

29 May 2018

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Modulating stress responses by the UPRosome: a matter of life and death

29 May 2018

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Autophagy in immunity and inflammation

29 May 2018

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Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

29 May 2018

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Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

29 May 2018

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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis

29 May 2018

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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

29 May 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

29 May 2018

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

29 May 2018

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

29 May 2018

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Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities

29 May 2018

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Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly

29 May 2018

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Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity

29 May 2018

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

29 May 2018

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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

29 May 2018

1 reference

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

29 May 2018

1 reference

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IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

29 May 2018

1 reference

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Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

29 May 2018

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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

29 May 2018

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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

29 May 2018

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Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy

29 May 2018

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A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

29 May 2018

1 reference

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Hyperlipidemia-induced hepatic and small intestine ER stress and decreased paraoxonase 1 expression and activity is associated with HDL dysfunction in Syrian hamsters.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. 1. Taxonomy, fermentation, isolation and biological activities

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5294857

17 August 2018

Identifiers

DOI

10.1084/JEM.20160791

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28082357%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28082357%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

28082357

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28082357%20AND%20SRC:MED&resulttype=core&format=json