Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke (Q42023698)

15 October 2017

Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke (English)

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15 October 2017

Marc L Otten

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15 October 2017

E Sander Connolly

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15 October 2017

Andrew F Ducruet

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15 October 2017

Brad E Zacharia

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15 October 2017

Nsikan Akpan

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15 October 2017

Esther Serrano-Saiz

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15 October 2017

Scott J Snipas

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15 October 2017

Wen Liu

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15 October 2017

Jennifer Velloza

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15 October 2017

Greg Cohen

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15 October 2017

Sergeyi A Sosunov

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15 October 2017

William H Frey

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15 October 2017

Guy S Salvesen

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15 October 2017

Carol M Troy

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15 October 2017

language of work or name

English

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publication date

1 June 2011

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15 October 2017

Journal of Neuroscience

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15 October 2017

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15 October 2017

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15 October 2017

8894-8904

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describes a project that uses

15 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3143191/fullTextXML

inferred from PubMed Central ID database lookup

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

5 June 2018

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Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation

5 June 2018

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5 June 2018

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5 June 2018

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Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

5 June 2018

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Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke.

5 June 2018

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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation

5 June 2018

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Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases

5 June 2018

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NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

5 June 2018

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Defects in regulation of apoptosis in caspase-2-deficient mice

5 June 2018

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Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

5 June 2018

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Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia

5 June 2018

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Neurological and behavioral outcomes of focal cerebral ischemia in rats

5 June 2018

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p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

5 June 2018

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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

17 August 2018

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Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue

17 August 2018

1 reference

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

17 August 2018

1 reference

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In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis

17 August 2018

1 reference

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PTD-XIAP protects against cerebral ischemia by anti-apoptotic and transcriptional regulatory mechanisms.

17 August 2018

1 reference

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Apoptosis inhibition in ischemic brain by intraperitoneal PTD-BIR3-RING (XIAP).

17 August 2018

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Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

17 August 2018

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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

17 August 2018

1 reference

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Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Clinicotopographical correlation of corticospinal tract stroke: a color-coded diffusion tensor imaging study

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Human caspase-7 activity and regulation by its N-terminal peptide.

17 August 2018

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Examination of sensorimotor performance following middle cerebral artery occlusion in rats

17 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Specific caspase pathways are activated in the two stages of cerebral infarction.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Intracerebral clysis in a rat glioma model.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Model development and behavioral assessment of focal cerebral ischemia in rats

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Monofilament intraluminal middle cerebral artery occlusion in the mouse.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143191

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

17 August 2018

1 reference

12 December 2020

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

1 reference

12 December 2020

Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation

1 reference

12 December 2020

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

1 reference

12 December 2020

The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats

1 reference

12 December 2020

Neurologic assessment of somatosensory dysfunction following an experimental rodent model of cerebral ischemia

1 reference

12 December 2020

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

1 reference

12 December 2020

10.1523/JNEUROSCI.0698-11.2011

Identifiers

DOI

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15 October 2017

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15 October 2017

PubMed publication ID

21677173

1 reference