Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. (Q45050796)

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1 January 2020

title

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease (English)

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David A Bennett

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Lester I Binder

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Kristina R Patterson

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Angela L Guillozet-Bongaarts

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Matthew R Reynolds

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Christopher A Carroll

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Susan T Weintraub

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Vincent L Cryns

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Robert W Berry

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language of work or name

English

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publication date

1 September 2004

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1 January 2020

published in

Journal of Neuroscience

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volume

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issue

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page(s)

7895-7902

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Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment

1 January 2020

cites work

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12 December 2020

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease

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12 December 2020

Formation of diffuse and fibrillar tangles in aging and early Alzheimer's disease.

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12 December 2020

Structure of tau protein and assembly into paired helical filaments

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12 December 2020

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

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12 December 2020

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

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12 December 2020

Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.

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12 December 2020

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease

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12 December 2020

Proapoptotic effects of tau cleavage product generated by caspase-3.

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12 December 2020

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment

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12 December 2020

Tau-66: evidence for a novel tau conformation in Alzheimer's disease

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12 December 2020

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease

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12 December 2020

Individual differences in rates of change in cognitive abilities of older persons

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12 December 2020

Natural history of mild cognitive impairment in older persons

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12 December 2020

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

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12 December 2020

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

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12 December 2020

Tau polymerization: role of the amino terminus

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12 December 2020

Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease.

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12 December 2020

Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site

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12 December 2020

Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment

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12 December 2020

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

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12 December 2020

Phosphorylation of tau by fyn: implications for Alzheimer's disease.

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12 December 2020

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

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12 December 2020

Structural characterization of the core of the paired helical filament of Alzheimer disease

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12 December 2020

Epitopes that span the tau molecule are shared with paired helical filaments.

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12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

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12 December 2020

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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12 December 2020

Alz-50 antibody recognizes Alzheimer-related neuronal changes

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12 December 2020

Immunohistochemical staging of neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

Evidence for apoptotic cell death in Alzheimer's disease.

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12 December 2020

Staging of Alzheimer's disease-related neurofibrillary changes

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12 December 2020

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

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12 December 2020

Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease

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12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

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12 December 2020

Mechanisms of neuronal death in Alzheimer's disease

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12 December 2020

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

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12 December 2020

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments

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12 December 2020

Substrate specificities of caspase family proteases

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12 December 2020

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

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12 December 2020

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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12 December 2020

Caspases: the executioners of apoptosis

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12 December 2020

Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease

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12 December 2020

Expression of ced-3 and ced-9 homologs in Alzheimer's disease cerebral cortex

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12 December 2020

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12 December 2020

Progression of Alzheimer histopathological changes.

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12 December 2020

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

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12 December 2020

10.1523/JNEUROSCI.1988-04.2004

Identifiers

DOI

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1 January 2020

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PubMed publication ID

15356202

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