Inhibition of FAK kinase activity preferentially targets cancer stem cells (Q41612992)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Inhibition of FAK kinase activity preferentially targets cancer stem cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

main subject

neoplastic stem cells

1 reference

Vihren N Kolev

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Winnie F Tam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Sean P McDermott

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Christian M Vidal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Irina M Shapiro

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Qunli Xu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Jonathan A Pachter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

David T Weaver

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

language of work or name

English

0 references

publication date

16 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

volume

1 reference

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29 March 2020

issue

1 reference

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29 March 2020

page(s)

51733-51747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

29 March 2020

cites work

1 reference

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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal

6 June 2018

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Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL.

6 June 2018

1 reference

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Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

6 June 2018

1 reference

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FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.

6 June 2018

1 reference

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Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

6 June 2018

1 reference

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ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling

6 June 2018

1 reference

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Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy

6 June 2018

1 reference

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Co-expression of uPAR and CXCR4 promotes tumor growth and metastasis in small cell lung cancer

6 June 2018

1 reference

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FAK in cancer: mechanistic findings and clinical applications

6 June 2018

1 reference

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Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship

6 June 2018

1 reference

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Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer

6 June 2018

1 reference

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Evolution of the cancer stem cell model

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

6 June 2018

1 reference

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Targeting FAK in human cancer: from finding to first clinical trials

6 June 2018

1 reference

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Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Distinct FAK activities determine progenitor and mammary stem cell characteristics

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Cancer stem cells: current status and evolving complexities

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survival

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Prevalence of epithelial ovarian cancer stem cells correlates with recurrence in early-stage ovarian cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

FAK and WNT signaling: the meeting of two pathways in cancer and development

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Focal adhesion kinase protein regulatesWnt3agene expression to control cell fate specification in the developing neural plate

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

6 June 2018

1 reference

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Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

6 June 2018

1 reference

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Targeting Wnt signaling: can we safely eradicate cancer stem cells?

6 June 2018

1 reference

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Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

6 June 2018

1 reference

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CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

6 June 2018

1 reference

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

6 June 2018

1 reference

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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

The signaling and biological implications of FAK overexpression in cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

FAK regulates biological processes important for the pathogenesis of cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Focal adhesion kinase: the first ten years

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Targeting breast cancer stem cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5584283

Aldehyde dehydrogenase 1-positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node-positive breast cancer

4 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28881682

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prevalence of the CTNNB1 mutation genotype in surgically resected fibromatosis of the breast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28881682

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.18517

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

28881682

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28881682%20AND%20SRC:MED&resulttype=core&format=json