Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome (Q41191920)

28 September 2017

Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome (English)

1 reference

28 September 2017

0 references

Marianna D'Anca

0 references

Matteo Marchesini

Matteo Marchesini

0 references

Paola Storti

Paola Storti

0 references

Simona Colla

Simona Colla

0 references

Marcos Estecio

Marcos Estecio

0 references

Nicola Giuliani

Nicola Giuliani

0 references

Lynda Chin

Lynda Chin

1 reference

28 September 2017

Hagop Kantarjian

1 reference

28 September 2017

Guillermo Garcia-Manero

Guillermo Garcia-Manero

1 reference

28 September 2017

Ronald A DePinho

1 reference

28 September 2017

Carlos Bueso-Ramos

1 reference

28 September 2017

Irene Ganan Gomez

1 reference

28 September 2017

Laurence J N Cooper

1 reference

28 September 2017

Asha S Multani

1 reference

28 September 2017

Sujun Hua

1 reference

28 September 2017

Yamini Ogoti

1 reference

28 September 2017

Derrick Sek Tong Ong

1 reference

28 September 2017

Andrea Viale

1 reference

28 September 2017

Giannicola Genovese

1 reference

28 September 2017

Luigi Nezi

1 reference

28 September 2017

Piergiorgio Pettazzoni

Piergiorgio Pettazzoni

1 reference

28 September 2017

Nipun A Mistry

1 reference

28 September 2017

Karen Clise-Dwyer

1 reference

28 September 2017

Sonny A Ang

1 reference

28 September 2017

Kathryn Ruisaard

1 reference

28 September 2017

Christopher A Bristow

1 reference

28 September 2017

David C Weksberg

1 reference

28 September 2017

Yan Wing Ho

1 reference

28 September 2017

Baoli Hu

1 reference

28 September 2017

Shan Jiang

1 reference

28 September 2017

Michael C Ryan

1 reference

28 September 2017

Alessandro Carugo

1 reference

28 September 2017

Yue Wei

1 reference

28 September 2017

Hui Yang

1 reference

28 September 2017

Li Zhang

1 reference

28 September 2017

Sarah Gaddis

1 reference

28 September 2017

Ting Gong

1 reference

28 September 2017

James W Horner

1 reference

28 September 2017

Timothy P Heffernan

1 reference

28 September 2017

Philip Jones

1 reference

28 September 2017

Han Liang

1 reference

28 September 2017

Y Alan Wang

1 reference

28 September 2017

1 May 2015

1 reference

28 September 2017

1 reference

28 September 2017

1 reference

28 September 2017

1 reference

28 September 2017

644-657

1 reference

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

PRPF8 defects cause missplicing in myeloid malignancies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Misregulation of pre-mRNA alternative splicing in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

The myelodysplastic syndrome as a prototypical epigenetic disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Detecting differential usage of exons from RNA-seq data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Axis of ageing: telomeres, p53 and mitochondria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

The ancient and evolving roles of cohesin in gene expression and DNA repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Dnmt3a is essential for hematopoietic stem cell differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Frequent pathway mutations of splicing machinery in myelodysplasia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

The Paf oncogene is essential for hematopoietic stem cell function and development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Clinical effect of point mutations in myelodysplastic syndromes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Differential expression analysis for sequence count data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

SR proteins and related factors in alternative splicing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Familial myelodysplasia and acute myeloid leukaemia--a review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Cell-cycle checkpoints and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

A DNA damage checkpoint response in telomere-initiated senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Senescence Induced by Altered Telomere State, Not Telomere Loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Essential role of mouse telomerase in highly proliferative organs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Splicing factor SF3b as a target of the antitumor natural product pladienolide

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Clonal architecture of chronic myelomonocytic leukemias

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

2 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596059

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25965571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25965571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25965571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCELL.2015.04.007

1 reference

28 September 2017

1 reference

28 September 2017

PubMed publication ID

25965571

1 reference