Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate (Q41166999)

27 September 2017

Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate (English)

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27 September 2017

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Izumi Maezawa

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27 September 2017

Lee-Way Jin

series ordinal

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27 September 2017

language of work or name

English

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publication date

1 April 2010

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27 September 2017

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inferred from page(s)

published in

Journal of Neuroscience

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27 September 2017

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27 September 2017

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27 September 2017

5346-5356

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describes a project that uses

27 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5533099/fullTextXML

inferred from PubMed Central ID database lookup

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Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions

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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

27 September 2017

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Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Rett syndrome: a Rosetta stone for understanding the molecular pathogenesis of autism

27 September 2017

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Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

27 September 2017

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27 September 2017

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Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

27 September 2017

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Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome

27 September 2017

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ATP mediates rapid microglial response to local brain injury in vivo

27 September 2017

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27 September 2017

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Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

27 September 2017

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Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

27 September 2017

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X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brain.

27 September 2017

1 reference

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Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Mitochondrial glutaminase enhances extracellular glutamate production in HIV-1-infected macrophages: linkage to HIV-1 associated dementia.

27 September 2017

1 reference

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Rett Syndrome -- an update

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

27 September 2017

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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

27 September 2017

1 reference

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Rett syndrome: clinical update and review of recent genetic advances.

27 September 2017

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Enhanced secretion of amylase from exocrine pancreas of connexin32-deficient mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Bax involvement in p53-mediated neuronal cell death

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

27 September 2017

1 reference

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

The release and uptake of excitatory amino acids

27 September 2017

1 reference

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Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Intracellular calcium changes trigger connexin 32 hemichannel opening

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Elevated CSF glutamate in Rett syndrome

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533099

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

19 August 2018

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A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome

19 August 2018

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Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice.

19 August 2018

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Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.

19 August 2018

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Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.

19 August 2018

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Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.

19 August 2018

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Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

19 August 2018

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GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.

19 August 2018

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Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists.

19 August 2018

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Vesicular glutamate transporter-dependent glutamate release from astrocytes.

19 August 2018

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High levels of cerebrospinal fluid glutamate in Rett syndrome

19 August 2018

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Neuropathology of Rett syndrome

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12 December 2020

A novel SNAP25-caveolin complex correlates with the onset of persistent synaptic potentiation

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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

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10.1523/JNEUROSCI.5966-09.2010

Identifiers

DOI

1 reference

27 September 2017

1 reference

27 September 2017

PubMed publication ID

20392956

1 reference