Cathelicidin antimicrobial peptide (Q411181)

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mammalian protein found in Homo sapiens

• CAP18
• epididymis secretory sperm binding protein
• cathelicidin antimicrobial peptide
• hCAP-18
• 18 kDa cationic antimicrobial protein
• CAMP
• CAMP(31-170)
• CAP-18

edit

Language	Label	Description	Also known as
English	Cathelicidin antimicrobial peptide	mammalian protein found in Homo sapiens	CAP18 epididymis secretory sperm binding protein cathelicidin antimicrobial peptide hCAP-18 18 kDa cationic antimicrobial protein CAMP CAMP(31-170) CAP-18

Statements

instance of

protein precursor

1 reference

stated in

Online Mendelian Inheritance in Man

exact match

https://www.omim.org/entry/600474

retrieved

18 August 2019

protein

1 reference

stated in

UniProt

retrieved

18 December 2019

UniProt protein ID

P49913

part of

CAMP

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P49913

PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)

0 references

Cathelicidin, antimicrobial peptide, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cathelicidin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

18 December 2019

UniProt protein ID

P49913

encoded by

CAMP

1 reference

stated in

UniProt

retrieved

22 April 2020

UniProt protein ID

P49913

Q118395394

1 reference

stated in

UniProt

UniProt protein ID

P49913

molecular function

lipopolysaccharide binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

cell component

extracellular region

determination method or standard

TAS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IEA

specific granule

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

extracellular exosome

determination method or standard

IDA

3 references

retrieved

26 September 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

extracellular space

determination method or standard

IDA

6 references

retrieved

26 September 2017

stated in

Proteolysis of human thrombin generates novel host defense peptides

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Antimicrobial peptides in the first line defence of human colon mucosa

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

extracellular space

determination method or standard

IBA

IDA

5 references

retrieved

8 April 2019

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

Antimicrobial peptides in the first line defence of human colon mucosa

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

specific granule

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

extracellular exosome

determination method or standard

HDA

2 references

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

HDA

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

HDA

biological process

defense response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IEA

innate immune response in mucosa

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Antimicrobial peptides in the first line defence of human colon mucosa

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

innate immune response

determination method or standard

IDA

IMP

6 references

retrieved

26 September 2017

stated in

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IMP

retrieved

26 September 2017

stated in

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

killing by host of symbiont cells

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

chronic inflammatory response

determination method or standard

IMP

1 reference

retrieved

26 September 2017

stated in

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IMP

defense response to bacterium

determination method or standard

IEA

IMP

TAS

4 references

retrieved

8 April 2019

stated in

The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

TAS

retrieved

8 April 2019

stated in

Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IEA

antimicrobial humoral response

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

TAS

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IDA

IMP

9 references

retrieved

26 September 2017

stated in

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IMP

retrieved

26 September 2017

stated in

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Proteolysis of human thrombin generates novel host defense peptides

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Antimicrobial peptides in the first line defence of human colon mucosa

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

26 September 2017

stated in

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

cytolysis by host of symbiont cells

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Proteolysis of human thrombin generates novel host defense peptides

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49913&geneProductId=UniProtKB:P49913

determination method or standard

IDA

innate immune response

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

defense response to Gram-negative bacterium

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

defense response to Gram-positive bacterium

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Antimicrobial peptides in the first line defence of human colon mucosa

GOA

curator

UniProt

UniProt protein ID

P49913

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49913

determination method or standard

IBA

Gene Atlas image

PBB GE CAMP 210244 at fs.png
732 × 530; 8 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P49913

1 reference

stated in

Identifiers.org

has part(s)

Cathelicidin, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P49913

Cathelicidin, antimicrobial peptide, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P49913

antibacterial peptide LL-37

0 references

antibacterial peptide FALL-39

0 references

Identifiers

RefSeq protein ID

NP_004336

1 reference

stated in

NCBI Gene

retrieved

27 December 2019

Entrez Gene ID

820

Reactome ID

R-HSA-5432964

0 references

UniProt protein ID

P49913

1 reference

stated in

UniProt

retrieved

18 December 2019

UniProt protein ID

P49913

Ensembl protein ID

ENSP00000296435

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000296435

ENSP00000498425

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000498425

Freebase ID

/m/027tv50

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Semantic Scholar topic ID

9993272

0 references

Transporter Classification Database ID

1.C.33.1.10

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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