Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. (Q41109181)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27432475%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors (English)

1 reference

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Mycobacterium tuberculosis

19 March 2020

main subject

0 references

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19 March 2020

1 reference

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19 March 2020

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19 March 2020

Madeline E Kavanagh

1 reference

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19 March 2020

Janine L Gray

1 reference

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19 March 2020

Sophie H Gilbert

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19 March 2020

Kirsty J McLean

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19 March 2020

Chris Abell

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19 March 2020

publication date

19 July 2016

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19 March 2020

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19 March 2020

volume

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19 March 2020

issue

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19 March 2020

page(s)

1924-1935

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Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

19 March 2020

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Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

26 September 2017

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Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes

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Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

26 September 2017

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Characterization of Active Site Structure in CYP121: A CYTOCHROME P450 ESSENTIAL FOR VIABILITY OF MYCOBACTERIUM TUBERCULOSIS H37Rv

26 September 2017

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Recent developments in fragment-based drug discovery

26 September 2017

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Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

26 September 2017

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Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods

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26 September 2017

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26 September 2017

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Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis

26 September 2017

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26 September 2017

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26 September 2017

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26 September 2017

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26 September 2017

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Fragment screening: an introduction

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7 January 2021

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Deconstructing fragment-based inhibitor discovery

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Fragment-based deconstruction of Bcl-xL inhibitors

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7 January 2021

Azole antifungals as novel chemotherapeutic agents against murine tuberculosis

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Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode

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Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27432475

12 December 2020

inferred from PubMed ID database lookup

Active site-directed inhibitors of cytochrome P-450scc. Structural and mechanistic implications of a side chain-substituted series of amino-steroids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27432475

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1002/CMDC.201600248

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27432475%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

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19 March 2020

PubMed publication ID

27432475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27432475%20AND%20SRC:MED&resulttype=core&format=json