Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases (Q35484644)

8 August 2017

title

Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases (English)

1 reference

protein-protein interaction

8 August 2017

main subject

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Anthony G Coyne

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Tom L Blundell

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8 August 2017

Duncan E Scott

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8 August 2017

Ashok Venkitaraman

series ordinal

1 reference

8 August 2017

Chris Abell

series ordinal

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8 August 2017

Marko Hyvönen

series ordinal

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8 August 2017

publication date

2 December 2014

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8 August 2017

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

296-303

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Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

8 August 2017

cites work

1 reference

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Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

27 July 2018

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Targeting protein-protein interactions as an anticancer strategy

27 July 2018

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Using a Fragment-Based Approach To Target Protein-Protein Interactions

27 July 2018

1 reference

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

27 July 2018

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Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

27 July 2018

1 reference

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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

27 July 2018

1 reference

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Fragment-based approaches in drug discovery and chemical biology

27 July 2018

1 reference

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

27 July 2018

1 reference

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

27 July 2018

1 reference

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Predicting druggable binding sites at the protein-protein interface.

27 July 2018

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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

27 July 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

27 July 2018

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Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons

27 July 2018

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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

27 July 2018

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Protein-protein interactions and cancer: small molecules going in for the kill

27 July 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

27 July 2018

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

27 July 2018

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

27 July 2018

1 reference

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

27 July 2018

1 reference

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The atomic structure of protein-protein recognition sites

27 July 2018

1 reference

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Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.

27 July 2018

1 reference

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Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

21 January 2018

1 reference

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A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

21 January 2018

1 reference

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The BRC repeats are conserved in mammalian BRCA2 proteins

21 January 2018

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The role of ligand efficiency metrics in drug discovery.

21 January 2018

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The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201402428

21 January 2018

Identifiers

DOI

10.1002/CMDC.201402428

1 reference

8 August 2017

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8 August 2017

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