Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus (Q40935835)

25 September 2017

title

Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus (English)

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alternative mRNA splicing, via spliceosome

25 September 2017

main subject

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Robertson KD

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25 September 2017

Jones PA

series ordinal

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25 September 2017

language of work or name

English

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publication date

1 July 1999

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25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

page(s)

3810-3820

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

25 September 2017

cites work

1 reference

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Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway

21 January 2018

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

21 January 2018

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

21 January 2018

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Parental imprinting of autosomal mammalian genes

21 January 2018

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Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

21 January 2018

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Splicing into Senescence: The Curious Case of p16 and p19ARF

21 January 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Germline p16 mutations in familial melanoma

21 January 2018

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation

21 January 2018

1 reference

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.

21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

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Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication

21 January 2018

1 reference

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The human protein p19ARF is not detected in hemopoietic human cell lines that abundantly express the alternative β transcript of the p16INK4a/MTS1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202737

Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element

21 January 2018

1 reference

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

21 January 2018

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The ANK repeat: a ubiquitous motif involved in macromolecular recognition

21 January 2018

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7 January 2021

RNA and the epigenetic regulation of X chromosome inactivation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202737

7 January 2021

The p16INK4a/CDKN2A tumor suppressor and its relatives.

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7 January 2021

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202737

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202737

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Dimensions Publication ID

25 September 2017

1041927117

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