TAN-1813, a novel Ras-farnesyltransferase inhibitor produced by Phoma sp. taxonomy, fermentation, isolation and biological activities in vitro and in vivo. (Q40842277)

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English	TAN-1813, a novel Ras-farnesyltransferase inhibitor produced by Phoma sp. taxonomy, fermentation, isolation and biological activities in vitro and in vivo.	scientific article

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2 November 2019

TAN-1813, a novel Ras-farnesyltransferase inhibitor produced by Phoma sp. taxonomy, fermentation, isolation and biological activities in vitro and in vivo (English)

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2 November 2019

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(2R,4S,4aS,5R,6R,8aR)-8a-hydroxy-4,6-dimethyl-5-[4-[(3R)-oct-1-en-3-yl]-2,5-dioxopyrrole-3-carbonyl]-2,3,4,4a,5,6-hexahydro-1H-naphthalene-2-carboxylic acid

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1,2,3,4,4a,5,6,8a-Octahydro-8abeta-hydroxy-4alpha,6alpha-dimethyl-5-[[4-[(S)-1-vinylhexyl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-3-yl]carbonyl]naphthalene-2alpha-carboxylic acid

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author name string

T Ishii

1

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2 November 2019

K Hayashi

2

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2 November 2019

T Hida

3

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2 November 2019

Y Yamamoto

4

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2 November 2019

Y Nozaki

5

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2 November 2019

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2000

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16 September 2022

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https://www.jstage.jst.go.jp/article/antibiotics1968/53/8/53_8_765/_pdf

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The Journal of Antibiotics

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2 November 2019

53

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2 November 2019

8

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2 November 2019

765-778

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2 November 2019

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The ras gene family and human carcinogenesis

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Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene

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Function and regulation of ras.

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Pathways of Ras function: connections to the actin cytoskeleton.

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Steady-state kinetic mechanism of Ras farnesyl:protein transferase

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The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae

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The p21 ras C-terminus is required for transformation and membrane association

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Identification of Ras farnesyltransferase inhibitors by microbial screening

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Farnesylamine: an inhibitor of farnesylation and growth of ras-transformed cells

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Cell cycle-specific effects of lovastatin

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

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Inhibitors of Ras farnesyltransferases

1 reference

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Friends and family: the role of the Rab GTPases in vesicular traffic

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Proteins regulating Ras and its relatives

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Kinetic Analysis of Zinc Ligand Mutants of Mammalian Protein Farnesyltransferase

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase

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Identifiers

10.7164/ANTIBIOTICS.53.765

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11079798%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11079798%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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